BACKGROUND Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. METHODS AND RESULTS Here, w...

This paper reports the results of our use of Cavity Ring Down Spectroscopy to extend the study of highly excited vibrational states in HCN. We extend our previous study of the HCN isotopomer, reporting on some weaker bands between 17 500 and 19 500 cm. We also report spectra of overtone and combination bands with six, seven, and eight quanta of stretching vibration in the isotopomers HCN and HC...

Prevalence is the best indicator of cancer survivorship in the population, but few studies have focused on brain tumor prevalence because of previous data limitations. Hence, the full impact of primary brain tumors on the healthcare system in the United States is not completely described. The present study provides an estimate of the prevalence of disease in the United States, updating an earli...

BACKGROUND Health insurance has many benefits including improved financial security, greater access to preventive care, and better self-perceived health. However, the influence of health insurance on major health outcomes is unclear. Sudden cardiac arrest prevention represents one of the major potential benefits from health insurance, given the large impact of sudden cardiac arrest on premature...

Most models of product adoption predict S-shaped adoption curves. Here we report results from two country-scale experiments in which we find linear adoption curves. We show evidence that the observed linear pattern is the result of active information-seeking behaviour: individuals actively pulling information from several central sources facilitated by modern Internet searches. Thus, a constant...

stroke is one of the most prevalent and disabling disease in human being. approximately 700000 strokes occur each year in the united states, leaving 500 000 stroke survivors with disability, and economic loss resulting from stroke approaches an estimated $51.2 billion annually 1 . what comes below is stroke management guideline used at massachusetts general hospital (at harvard medical school) ...