OBJECTIVE Renal dopamine receptor D1 played a critical role in the regulation of body blood pressure. Under hypertension, over-phosphorylation of D1 receptor impaired its function. G protein kinase 4 (GRK4) and protein phosphatase 2A (PP2A) exerted the effect to phosphorylate and de-phosphorylate D1 receptor. A current study revealed that the inhibition of GRK4 cannot normalize the phosphorylat...

The cyclin D1 gene is amplified and overexpressed in human breast cancer, functioning as a collaborative oncogene. As the regulatory subunit of a holoenzyme phosphorylating Rb, cyclin D1 promotes cell cycle progression and a noncatalytic function has been described to sequester the cyclin-dependent kinase inhibitor protein p27. Cyclin D1 overexpression correlates with tumor metastasis and cycli...

2.1 The Case All di 6= 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.2 The Case d0 = 0 < d1 ≤ d2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 The Case d0 < 0 = d1 < d2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.4 The Case d0 ≤ d1 < d2 = 0 . . . . . . . . . . . . . . . . . . . . . . . ...

A macroscopic approximation of RNA secondary structure (Vialette, CPM 2002): • a subsequence of consecutive bases → an interval • a stacked pairing of two disjoint subsequences → a 2interval Three Binary Relations For two 2-intervals D1 = (I1, J1) and D2 = (I2, J2), D1 and D2 are disjoint if the four intervals I1, J1, I2, and J2 are pairwise disjoint. Preceding: D1 < D2 ⇐⇒ I1 < J1 < I2 < J2. Ne...

The cyanobacterium Synechococcus sp. PCC 7942 possesses a small psbA multigene family that codes for two distinct forms of the photosystem II reaction-center protein D1 (D1:1 and D1:2). We showed previously that the normally predominant D1 form (D1:1) was rapidly replaced with the alternative D1:2 when cells adapted to a photon irradiance of 50 mumol.m-2.s-1 are shifted to 500 mumol.m-2.s-1 and...