Transgenic overexpression of the Notch1 intracellular domain inhibits osteoblast differentiation and causes osteopenia, and inactivation of Notch1 and Notch2 increases bone volume transiently and induces osteoblastic differentiation. However, the biology of Notch is cell-context-dependent, and consequences of Notch activation in cells of the osteoblastic lineage at various stages of differentia...

The Rapid Office Strain Assessment (ROSA) was designed to quickly quantify risks associated with computer work and to establish an action level for change based on reports of worker discomfort. Computer use risk factors were identified in previous research and standards on office design for the chair, monitor, telephone, keyboard and mouse. The risk factors were diagrammed and coded as increasi...

Apoptosis is one way of controlling immune responses, and a variety of immunosuppressive drugs suppress harmful immune responses by inducing apoptosis of lymphocytes. In this study we observed that rosmarinic acid, a secondary metabolite of herbal plants, induced apoptosis in an p56(lck) (Lck)-dependent manner; Lck(+) Jurkat T cells undergo apoptosis in response to rosmarinic acid (RosA) treatm...

Nature of Work: ‘Santa Rosa’ magnolia, a selection of the native Magnolia virginiana L. (Sweet Bay magnolia) introduced by Woodlanders Nursery, Aiken, S.C. in 1979, is an upright, evergreen tree with an open growth habit. Leaves of ‘Santa Rosa’ are larger than the species as are the lemon scented flowers (Raulston, personal communication). These attributes along with height growth that approach...

Plants have an important place in human life many sectors for years. Rosa damascena Mill plant, which is called Pink Oil Rose, a species that has economic value such as cosmetics, perfume, medicine and food industry with its distinctive sharp intense scent among rose varieties. harvested May Turkey when buds bloom. Roses bud form are left unharvested until they In this study, binary classificat...

In this study, the genetic diversity of 12 Iranian Damask rose (Rosa damascena Mill.) genotypes was studied using amplified fragment length polymorphism (AFLP) markers. Twelve AFLP primer combinations generated 483 polymorphic bands and showed extreme variability and genetic complexity among the studied genotypes. The AFLP analysis revealed a specific amplified fragment for the genotypes collec...

Rosmarinic acid (RosA) is a water-soluble polyphenol, which can be isolated from many herbs such as orthosiphon diffuses and rosmarinus officinalis. Previous studies have shown that RosA possesses various biological properties. In this study, we investigate the anti-osteoarthritic effects of RosA in rat articular chondrocytes. Chondrocytes were pre-treated with RosA, followed by the stimulation...