Activation-induced cytidine deaminase (AID) is shown to be essential and sufficient to induce two genetic alterations in the Ig loci: class switch recombination (CSR) and somatic hypermutation (SHM). However, it is still unknown how a single-molecule AID differentially regulates CSR and SHM. Here we identified Spt6 as an AID-interacting protein by yeast two-hybrid screening and immunoprecipitat...

There are no translations available. Corporate social responsibility (CSR) has become a dominant theme in business and literature. Many studies speak about corporate social innovation and considered companies facing with additional goals that are innovation and CSR. The research aim of this work starts to look at the relationship among CSR and innovation as a value-creating process which occur ...

Ig class-switch recombination (Ig-CSR) deficiencies are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect, defective Ig-CSR may also be associated with impaired somatic hypermutation (SHM) of the Ig V regions. Although the mechanisms underlying Ig-CSR and SHM in humans have been revealed (at least in part) by ...

In this paper C-Slow Retiming (CSR) on RTL is discussed. CSR multiplies the functionality of cores by adding the same number of registers into each path. The technique is ideal for FPGAs with their already existing registers. Previously publications are limited to adding registers on netlist level, which generates a lot of system verification problems and which is assumed to be the major drawba...

Based on group creativity framework, our research investigates how corporate social responsibility (CSR) promotes innovation of firms by revealing sequential mediating mechanisms of employee’s meaningfulness of work and intrinsic motivation. By applying a multi-level approach, this study examines the internal processes of micro-level variables between two macro-level variables (i.e., CSR and in...

r 200 6 eber@un a.de/csm Summary Although theoretical and empirical research often points to a positive relation between CSR and company competitiveness, approaches to measure the company-specific business impacts of CSR are missing in the current literature. However, such an approach could strengthen the overall CSR involvement and support rational decision-making in this area. This paper thus...

Task-cuing paradigms are typically taken to explore control of task-set. However, they can be construed as requiring not selection of a task-set, just retrieval of a cue+stimulus->response (CSR) mapping. In this paper we considered performance in a task-cuing paradigm in which participants saw a color cue that indicated whether they should classify a digit as odd/even or high/low using one of t...

This study examines the relationship between firm innovation and CSR. Stakeholders’ concern over transaction-specific investments exacerbates when firms engage heavily in innovation activities. To secure stakeholders’ support, firms adopt CSR effectively as an ex ante signal of sustainability and goodwill. As CSR is endogenous to a firm’s innovation activities, we rely on an instrumental variab...

Corporate social responsibility is one among the top prioritized agenda of any business organization. Many business organizations embraced CSR in a befitting manner and are evident from the number of activities undertaken by them. This paper aims to study the factors influencing the CSR initiatives of the banks in Sultanate of Oman. This is based on the major stakeholders’ perspective towards p...

This paper contributes to addressing the paucity of works on corporate social responsibility (CSR) in Bangladesh by reporting on the findings of an exploratory study conducted in Dhaka in 2009 for the purpose of examining the views of a group of Bangladeshi managers from various sectors in relation to CSR. The findings revealed a significant level of awareness among the participants about CSR-r...