Transforming growth factor-beta (TGF-beta) is a potent inhibitor of growth factor-stimulated hematopoiesis in normal and leukemic conditions. Using the factor-dependent myelogenous leukemia cell lines GF-D8 and Mo7, we show that TGF-beta interferes with stem cell factor (SCF)-induced proliferation by downmodulating c-jun gene expression. The ability of SCF to induce accumulation of c-jun transc...

Genetic factors are known to influence host resistance to certain tumors . In the mouse, resistance has been linked to the MHC locus on chromosome 17 (1-4) . H-2 genes or other closely linked genes may be responsible, and natural resistance to transplantable lymphomas represents one case where these two possibilities have not been resolved (5) . A distinct set of H-2-linked "hemopoietic histoco...

Risk stratification and treatment intensification, based on minimal residual disease (MRD) mensurement, changed the prognosis of pediatric patients with acute lymphocytic leukemia (ALL). The main aim of this study was to investigate whether peripheral blood (PB) MRD measurement at day 8 (D8) could predict the risk stratification category determined by bone marrow (BM) MRD at day 15 (D15). The s...

The effective treatment of diseases of the nail remains an important unmet medical need, primarily because of poor drug delivery. To address this challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been visualized and characterized using stimulated Raman scattering (SRS) microscopy. Deuterated water (D2O), propylene glycol (PG-d8), and dimethyl sulphox...

The low-energy supersymmetric quantum mechanics describing D-particles in the background of D8-branes and orientifold planes is analyzed in detail, including a careful discussion of Gauss’ law and normal ordering of operators. This elucidates the mechanism that binds Dparticles to an orientifold plane, in accordance with the predictions of heterotic/type I duality. The ocurrence of enhanced sym...