نتایج جستجو برای: ژن stk11

تعداد نتایج: 16599  

Journal: :Physiological reviews 2009
Marnix Jansen Jean Paul Ten Klooster G Johan Offerhaus Hans Clevers

Research on the LKB1 tumor suppressor protein mutated in cancer-prone Peutz-Jeghers patients has continued at a feverish pace following exciting developments linking energy metabolism and cancer development. This review summarizes the current state of research on the LKB1 tumor suppressor. The weight of the evidence currently indicates an evolutionary conserved role for the protein in the regul...

2010
Xin Wang Dan Meng Qingshan Chang Jingju Pan Zhuo Zhang Gang Chen Zunji Ke Jia Luo Xianglin Shi

BACKGROUND Arsenic (As) is an environmental pollutant that induces numerous pathological effects, including neurodevelopmental disorders. OBJECTIVES AND METHODS We evaluated the role of the LKB1-AMPK pathway in As-induced developmental neurotoxicity using Neuro-2a (N2a) neuroblastoma cells as a model of developing neurons. RESULTS The addition of low concentrations of As (<or= 5 microM) dur...

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