نتایج جستجو برای: ژن pten

تعداد نتایج: 25032  

2017
Angela Mauro Ebun Omoyinmi Neil James Sebire Angela Barnicoat Paul Brogan

Phosphatase and tensin homolog (PTEN) is the protein encoded by the PTEN gene (10q23.3). PTEN mutations are related to a variety of rare diseases referred to collectively as PTEN hamartoma tumor syndromes (PHTS), which include Cowden Syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus Syndrome, and Proteus-like syndrome. These diseases are associated with an increased risk of malignancy and fo...

Journal: :Cancer research 2005
Andrew Xiao Chaoying Yin Chunyu Yang Antonio Di Cristofano Pier Paolo Pandolfi Terry Van Dyke

High-grade astrocytomas are invariably deadly and minimally responsive to therapy. Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. However, the Pten astrocytoma suppression mechanisms are unknown. Here we introduced conditional null alleles of Pten (Pten(loxp/loxp)) into a genetically engineered mouse astrocytoma model [TgG(deltaZ)T121] in which the pRb fa...

2014
Rachel Abbotts Rosalyn Jewell Jérémie Nsengimana David J Maloney Anton Simeonov Claire Seedhouse Faye Elliott Jon Laye Christy Walker Ajit Jadhav Anna Grabowska Graham Ball Poulam M Patel Julia Newton-Bishop David M Wilson Srinivasan Madhusudan

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activity. In the current study we explored a synthetic lethal relationship between PTEN and APE1 in melanoma. Clinicopathological significance of P...

Journal: :Anatomical record 2009
Qi-Yan Cai Xing-Shu Chen Shan-Chuan Zhong Xue Luo Zhong-Xiang Yao

The tumor suppressor phosphatase and tensin homologue (PTEN) is a protein and lipid phosphatase. PTEN mutations have been associated with a large number of human cancers. To understand the physiological role of PTEN in the brain and its relationship to Akt in ischemic injury, we first investigated the localization of PTEN immunoreactivity in the brains of normal adult rats using immunohistochem...

2015
Hui Wang Peng Zhang Chunhua Lin Qingxia Yu Jitao Wu Lin Wang Yupeng Cui Ke Wang Zhenli Gao Hong Li

PTEN-Long is a translational variant of PTEN (Phosphatase and Tensin Homolog). Like PTEN, PTEN-Long is able to antagonize the PI3K-Akt pathway and inhibits tumor growth. In this study, we investigated the role PTEN-Long plays in the development and progression of clear cell renal cell carcinoma (ccRCC) and explored the therapeutic possibility using proteinaceous PTEN-Long to treat ccRCC. We fou...

Journal: :The Biochemical journal 2008
Younghee Ahn Chae Young Hwang Seung-Rock Lee Ki-Sun Kwon Cheolju Lee

The tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10; a phosphatidylinositol 3-phosphatase) is a multifunctional protein deregulated in many types of cancer. It is suggested that a number of proteins that relate with PTEN functionally or physically have not yet been found. In order to search for PTEN-interacting proteins that might be crucial in the regulation o...

Journal: :Molecular and cellular biology 2005
Juinn-Lin Liu Xiaoyang Sheng Zsuzsanna K Hortobagyi Zhenyu Mao Gary E Gallick W K Alfred Yung

The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the cytoplasm and nucleus in normal cells, with a preferential nuclear localization in differentiated or resting cells. To elucidate the relationship between PTEN's subcellular localization and its biologic activities, we c...

Journal: :Genes & development 2015
Nan Li Yajie Zhang Xin Han Ke Liang Jiadong Wang Lin Feng Wenqi Wang Zhou Songyang Chunru Lin Liuqing Yang Yonghao Yu Junjie Chen

PTEN [phosphatidylinositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a phosphatase and critical tumor suppressor, is regulated by numerous post-translational modifications, including phosphorylation, ubiquitination, acetylation, and SUMOylation, which affect PTEN localization and protein stability. Here we report ADP-ribosylation as a new post-translation...

Journal: :The Journal of Experimental Medicine 2004
Thijs J. Hagenbeek Marianne Naspetti Fabrice Malergue Fabien Garçon Jacques A. Nunès Kitty B.J.M. Cleutjens Jan Trapman Paul Krimpenfort Hergen Spits

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases. We have explored the role of the phosphoinositol(3,4,5)P3-phosphatase PTEN in T cell development by analyzing mice with a T cell-specific deletion of PTEN. Pten(flox/flox)Lck-Cre mice developed thymic lymphomas, but before the onset of ...

2011
Tamara L. Lotan Bora Gurel Siobhan Sutcliffe David Esopi Wennuan Liu Jianfeng Xu Jessica L. Hicks Ben H. Park Elizabeth Humphreys Alan W. Partin Misop Han George J. Netto William B. Isaacs Angelo M. De Marzo

Purpose: Analytically validated assays to interrogate biomarker status in clinical samples are crucial for personalized medicine. PTEN is a tumor suppressor commonly inactivated in prostate cancer that has been mechanistically linked to disease aggressiveness. Though deletion of PTEN, as detected by cumbersome FISH spot counting assays, is associated with poor prognosis, few studies have valida...

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