نتایج جستجو برای: ژن pgc1α
تعداد نتایج: 16210 فیلتر نتایج به سال:
Skeletal muscle insulin resistance manifests as a decreased ability of insulin to stimulate glucose uptake in consequence of an impairment in its intracellular signaling. Sirtuin 1 (SIRT1), which belongs to the family of sirtuins (Sir2; silent information regulator 2 protein) participates in the regulation of skeletal muscle glucose and lipid metabolism. Experimental studies indicate that SIRT1...
The growing epidemic of type 2 diabetes mellitus (T2DM) and obesity is largely attributed to the current lifestyle of over-consumption and physical inactivity. As the primary platform controlling metabolic and energy homeostasis, mitochondria show aberrant changes in T2DM and obese subjects. While the underlying mechanism is under extensive investigation, epigenetic regulation is now emerging t...
Neural activity is tightly coupled to energy consumption, particularly sugars such as glucose. However, we find that, unlike mature neurons and astrocytes, neural stem/progenitor cells (NSPCs) do not require glucose to sustain aerobic respiration. NSPCs within the adult subventricular zone (SVZ) express enzymes required for fatty acid oxidation and show sustained increases in oxygen consumption...
The transcription factor EB (TFEB) is an essential component of lysosomal biogenesis and autophagy for the adaptive response to food deprivation. To address the physiological function of TFEB in skeletal muscle, we have used muscle-specific gain- and loss-of-function approaches. Here, we show that TFEB controls metabolic flexibility in muscle during exercise and that this action is independent ...
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other disea...
Submit Manuscript | http://medcraveonline.com Abbreviations: APOA1: Apolipoprotein A1; APOB: Apolipoprotein B; ATP: Adenosine Triphosphate; BMI: Body Mass Index; CRP: Cardio-Reactive Protein; DAG: Diacylglycerol or Diglyceride; FACoA: Fatty Acyl CoA; HbA1C: Hemoglobin A1c; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance; HDL: High-Density Lipoprotein cholesterol; HSCRP: Highly Sensi...
Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments imp...
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