نتایج جستجو برای: ژن nfkb
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Mdx mice develop an inflammatory myopathy characterized at different ages by myonecrosis with scattered inflammatory infiltrates followed by muscular regeneration and later persistent fibrosis. This work aimed to verify the putative anti-inflammatory role of nicotinic acetylcholine receptor (nAChR) in the mdx muscular lesion. Mitigation of myonecrosis and decreased TNFα production were accompan...
You find that inhibition of MEK promoted growth of xenografted or human primary leukemic cells in co-culture with stromal cells and that inhibition of MEK specifically in stromal cells promoted TALL cell proliferation. You also find IL-18 as major secreted factor and confirm that T-ALL cells have IL-18 receptors and a portion of samples are stimulated by IL-18, possibly via NFkB. We appreciate ...
We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1 inflammatory activity, absent during the ...
Abstract Purpose Atherosclerosis is an inflammatory process that particularly accelerated in diabetics, leading to increased incidence of cardiovascular diseases such as CAD and PAD diabetic patients. Monocytes are the main component atherosclerosis development. SHP-2 tyrosine phosphatase has been identified important regulator monocyte function. The present study therefore aims investigate reg...
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