HLA class I and KIR sequences were determined for Dogon, Fulani, Baka populations of western Africa, Mbuti central Datooga, Iraqw, Hadza eastern Africa. Study 162 individuals identified 134 alleles (41 HLA-A, 60 HLA-B, 33 HLA-C). Common to all are three HLA-C (C1+C*07:01, C1+C*07:02, C2+C*06:02) but ...

【背景】HLA抗体による血小板輸血不応症例には，HLA適合血小板（PC-HLA）が推奨される．ドナーの選定には，HLA-A座，B座の適合性を確認するが，HLA-C座の適合性は優先されない．本研究では，HLA-C座の適合性による輸血効果を解析した．【方法】関東甲信越ブロックにおいてHLA-C抗体による交差適合試験陽性例の輸血効果を解析した．また，東京大学医学部附属病院においてHLA抗体を保有する血小板輸血不応患者1例に対してPC-HLA（66本），適合血小板（19本）およびランダムの血小板製剤（7本）について，輸血効果を評価し，後追いの交差適合試験を実施した．【結果】交差適合試験陽性57件（陽性率0.25%）のうちHLA-C抗体によるものは27件（47.4％）であり，Cw8抗体が55.0%を占めていた．HLA-C座不一致製剤の75％は有効であった．東大01症例はCw15抗体陽性かつCw...

Objective To better characterize the genetic association between human leukocyte antigen (HLA) and anti-IgLON5 disease to explore auto-antigen binding associated HLA molecules their functional involvement in pathophysiology. Background Anti-IgLON5 is a rare, but likely underdiagnosed type of autoantibody encephalitis with heterogeneous clinical phenotype, including sleep, movement brainstem dys...

Background Specific haplotypes of human leukocyte antigen (HLA) are associated with susceptibility and disease activity Behçet’s (BD). However, the clinical importance HLA-A26 in BD is not well recognized compared to that HLA-B51. Objectives This study aimed examine association between HLA-A26, HLA-B51, manifestations, severity BD, especially focusing on possession. Methods was a multicenter cr...

Objective To explore genetic association between human leukocyte antigen (HLA) and neurodegenerative diseases investigate mechanisms behind the association. Background Pathophysiology of Alzheimer's disease (AD), Parkinson's (PD) amyotrophic lateral sclerosis (ALS) involves accumulation tau (neurofibrillary tangles) amyloid-ß-rich (amyloid plaques) aggregates in AD, a-synuclein-rich (Lewy bodie...

Đặt vấn đề: Gen HLA (kháng nguyên bạch cầu người) nằm trên nhánh ngắn nhiễm sắc thể số 6, được chia thành 3 lớp với các locus gen khác nhau. Việc xác định kiểu là rất cần thiết trong ghép, đặc biệt ghép tế bào gốc tạo máu. Đối tượng và phương pháp: Nghiên cứu cắt ngang tỷ lệ allele HLA-A, HLA-B, HLA-C HLA-DRB1 138 người cho máu tại Bệnh viện Nhi Trung ương từ năm 2010 - 2020. Kiểu bằng pháp PCR...

Objectives: Despite the improvements in early-term outcomes of kidney transplantation, late-term graft failure still remained as a critical problem. De novo donor specific antibodies (DSA) developing against direct human leukocyte antigens (HLA) are significant risk factors for shortened survival previously non-sensitized cases. The purpose this study is to evaluate clinical de DSA development ...

Introduction Several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of Meniere’s disease. The aim of this study was determining the association between HLA-Cw Alleles in patients with definite Meniere’s disease and patients with probable Meniere’s disease and a control group.  Materials and Methods: HLA-Cw genotyping was performed in 23 patients with def...

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...