نتایج جستجو برای: ژن he4
تعداد نتایج: 16408 فیلتر نتایج به سال:
Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of preneoplastic metaplasias in the stomach are limited by the sole reliance on in vivo mouse models, owing to the lack of in vitro models for distinct normal mucosal lineages and metaplasias. Utilizing the Immortomouse, in vitro cell models of chief ...
Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes. The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. The candidate genes with mucinous hist...
Purpose: To generate a comprehensive "Secretome" of proteins potentially found in the blood and derive a virtual Affymetrix array. To validate the utility of this database for the discovery of novel serum-based biomarkers using ovarian cancer transcriptomic data. ExperimentalDesign: The secretomewas constructed by aggregating the data from databases of known secreted proteins, transmembrane or ...
Abstract Background Cardiac fibrosis is one of the main causes diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF). Human epididymis protein 4 (HE4) a novel pro-fibrotic expressed especially activated fibroblast, so-call myofibroblast [1]. Although our previous study showed that HE4 functioned as secretory factor promoting cardiac dilated cardiomyopathy [2], little k...
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