The vertebrate sarcomere is a complex and highly organized contractile structure whose assembly and function requires the coordination of hundreds of proteins. Proteins require proper folding and incorporation into the sarcomere by assembly factors, and they must also be maintained and replaced due to the constant physical stress of muscle contraction. Zebrafish mutants affecting muscle assembl...

Dein (2002) comments on our editorial on explanatory models (Bhui & Bhugra, 2002), but fails to apprehend the conceptual flaws in his assertions, promotes a complacent attitude to the challenges of cultural psychiatry, and is threatened by a patient’s explanatory model that differs from his own. Dein agrees with us that explanatory models are not stable, and are dynamic, complex, shifting entit...

Dein (2002) comments on our editorial on explanatory models (Bhui & Bhugra, 2002), but fails to apprehend the conceptual flaws in his assertions, promotes a complacent attitude to the challenges of cultural psychiatry, and is threatened by a patient’s explanatory model that differs from his own. Dein agrees with us that explanatory models are not stable, and are dynamic, complex, shifting entit...

Dein (2002) comments on our editorial on explanatory models (Bhui & Bhugra, 2002), but fails to apprehend the conceptual flaws in his assertions, promotes a complacent attitude to the challenges of cultural psychiatry, and is threatened by a patient’s explanatory model that differs from his own. Dein agrees with us that explanatory models are not stable, and are dynamic, complex, shifting entit...

Dein (2002) comments on our editorial on explanatory models (Bhui & Bhugra, 2002), but fails to apprehend the conceptual flaws in his assertions, promotes a complacent attitude to the challenges of cultural psychiatry, and is threatened by a patient’s explanatory model that differs from his own. Dein agrees with us that explanatory models are not stable, and are dynamic, complex, shifting entit...

Dein (2002) comments on our editorial on explanatory models (Bhui & Bhugra, 2002), but fails to apprehend the conceptual flaws in his assertions, promotes a complacent attitude to the challenges of cultural psychiatry, and is threatened by a patient’s explanatory model that differs from his own. Dein agrees with us that explanatory models are not stable, and are dynamic, complex, shifting entit...

Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac development. Such defects occur in distinct regions or chambers of the heart. A molecular framework in which to consider cardiac development and congenital heart disease in a segmental fashion has begun to emerge. dHAND and eHAND are two related basic helix-loop-helix transcription factors that are express...