نتایج جستجو برای: ژن asc

تعداد نتایج: 19129  

Journal: :Journal of abnormal psychology 2015
Rose A Cooper Kate C Plaisted-Grant Deborah E Hannula Charan Ranganath Simon Baron-Cohen Jon S Simons

Subtle memory deficits observed in autism spectrum conditions (ASC) have often been characterized as reflecting impaired recollection and it has been proposed that a relational binding deficit may underlie the recollection impairment. However, subjective recollection and relational binding have not been measured within the same task in ASC to date and it is unclear whether a relational binding ...

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2017
Nélida I. Noguera Elvira Pelosi Daniela F. Angelini Maria Liliana Piredda Gisella Guerrera Eleonora Piras Luca Battistini Lauretta Massai Anna Berardi Gianfranco Catalano Laura Cicconi Germana Castelli Agnese D’Angiò Luca Pasquini Grazia Graziani Giuseppe Fioritoni Maria Teresa Voso Domenico Mastrangelo Ugo Testa Francesco Lo-Coco

The use of high-dose ascorbate (ASC) for the treatment of human cancer has been attempted several decades ago and has been recently revived by several in vitro and in vivo studies in solid tumors. We tested the cytotoxic effects of ASC, alone or in combination with arsenic trioxide (ATO) in acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). Leukemic cell lines and primary blas...

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2014
Mark J. Taylor Tony Charman Elise B. Robinson Marianna E. Hayiou-Thomas Francesca Happé Philip S. Dale Angelica Ronald

Language difficulties have historically been viewed as integral to autism spectrum conditions (ASC), leading molecular genetic studies to consider whether ASC and language difficulties have overlapping genetic bases. The extent of genetic, and also environmental, overlap between ASC and language is, however, unclear. We hence conducted a twin study of the concurrent association between autistic...

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Journal: :Social neuroscience 2006
Chris Ashwin Emma Chapman Livia Colle Simon Baron-Cohen

Autism and Asperger Syndrome are autism spectrum conditions (ASC) characterized by deficits in understanding others' minds, an aspect of which involves recognizing emotional expressions. This is thought to be related to atypical function and structure of the amygdala, and performance by people with ASC on emotion recognition tasks resembles that seen in people with acquired amygdala damage. In ...

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2017
Robert P. Gersch Joshua Glahn Michael G. Tecce Anthony J. Wilson Ivona Percec

Background Adipose-derived stem cells (ASCs) are a powerful tool for cosmetic surgery and regenerative medicine. The use of autologous platelet rich plasma (PRP), particularly in combination with ASC-based therapy, has significantly expanded in recent years. Unfortunately, the mechanisms and optimal dosing responsible for the beneficial effects of PRP remain poorly understood. Here we investiga...

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2007
Mindy Reynolds Lauren Stoddard Ivan Bespalov Anatoly Zhitkovich

Here we examined the role of cellular vitamin C in genotoxicity of carcinogenic chromium(VI) that requires reduction to induce DNA damage. In the presence of ascorbate (Asc), low 0.2-2 microM doses of Cr(VI) caused 10-15 times more chromosomal breakage in primary human bronchial epithelial cells or lung fibroblasts. DNA double-strand breaks (DSB) were preferentially generated in G2 phase as det...

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2011
Dalia H. A. Abdelaziz Mikhail A. Gavrilin Anwari Akhter Kyle Caution Sheetal Kotrange Arwa Abu Khweek Basant A. Abdulrahman Zeinab A. Hassan Fathia Z. El-Sharkawi Simranjit S. Bedi Katherine Ladner M. Elba Gonzalez-Mejia Andrea I. Doseff Mahmoud Mostafa Thirumala-Devi Kanneganti Dennis Guttridge Clay B. Marsh Mark D. Wewers Amal O. Amer

The apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) is an adaptor molecule that mediates inflammatory and apoptotic signals. Legionella pneumophila is an intracellular bacterium and the causative agent of Legionnaire's pneumonia. L. pneumophila is able to cause pneumonia in immuno-compromised humans but not in most inbred mice. Murine macrophages that lack ...

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Journal: :Autism research : official journal of the International Society for Autism Research 2009
Jennifer L Barnes Michael V Lombardo Sally Wheelwright Simon Baron-Cohen

People with autism spectrum conditions (ASC) have difficulties with mentalizing, empathy, and narrative comprehension. A new test of social and narrative cognition, the Moral Dilemmas Film Task, was developed to probe individuals' spontaneous understanding of naturalistic film scenes. Twenty-eight individuals with ASC and 28 neurotypical controls, matched for age, sex, and IQ, watched four shor...

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Journal: :Infection and immunity 1990
L Van de Verg D A Herrington J R Murphy S S Wasserman S B Formal M M Levine

The ability of bivalent Salmonella typhi-Shigella sonnei vaccine strain 5076-1C to stimulate an intestinal immunoglobulin A response in humans was evaluated by detecting gut-derived, trafficking antibody-secreting cells (ASC) in peripheral blood. Following vaccination, an immunoglobulin A-ASC response to O antigens of S. typhi and S. sonnei was observed in 10 of 13 and 13 of 13 vaccine recipien...

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2016
Tao Zhang Chieh Tseng Yan Zhang Olga Sirin Paul G Corn Elsa M Li-Ning-Tapia Patricia Troncoso John Davis Curtis Pettaway John Ward Marsha L Frazier Christopher Logothetis Mikhail G Kolonin

White adipose tissue (WAT) overgrowth in obesity is linked with increased aggressiveness of certain cancers. Adipose stromal cells (ASCs) can become mobilized from WAT, recruited by tumours and promote cancer progression. Mechanisms underlying ASC trafficking are unclear. Here we demonstrate that chemokines CXCL1 and CXCL8 chemoattract ASC by signalling through their receptors, CXCR1 and CXCR2,...

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