Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Re...

Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical pres...

background: in addition to human leukocyte antigens (hla) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. objective: to evaluate the influence of hla-dr matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (lurd) kidney transplantation. methods: a total of 42 renal transplants pe...

introduction several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of meniere’s disease. the aim of this study was determining the association between hla-cw alleles in patients with definite meniere’s disease and patients with probable meniere’s disease and a control group.  materials and methods: hla-cw genotyping was performed in 23 patients with def...

background: non-hodgkin lymphoma (nhl) includes a wide range of diseases with different clinical and biological features. nhl is usually presented as localized or generalized lymphadenopathy. it has been suggested that the hla class i and ii are associated with susceptibility to nhl. different ethnic groups have been found to have different hla class i and ii alleles which affect nhl. objective...

background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous stud...

Abstract T-cell receptor mimic antibodies (TCRm) have become an attractive therapeutic modality group as they allow for the targeting of intracellular proteins presented by HLA, which may a large potential new targets. However, polymorphic nature classical HLA class I and findings downregulation in cancer cells might limit use these agents treatment. An alternative approach would be to target p...

background and objective: the outcome of hepatitis b virus (hbv) infection may be influenced by host factors like human leukocyte antigen (hla). we have investigated hla-a and drb1 alleles in patients with persistent hepatitis b infection compared to subjects who had spontaneously recovered from hbv infection. to complete the findings of this study we performed another survey in certain hla all...

BACKGOUND: The prevalence of rheumatoid arthritis (RA) and its specific autoantibodies varies in different populations. This variability depends on the genetic polymorphism immune response genes among which HLA system plays a major role. AIM: We conducted preliminary study distribution HLA-DRB1 HLA-DQB1 first field level alleles sample 100 Albanian patients with RA. METHODS: In this context, we...