The endothelial cytoskeleton plays a key role in arterial responses to acute changes in shear stress. We evaluated whether the intermediate filament protein vimentin is involved in the structural responses of arteries to chronic changes in blood flow (BF). In wild-type mice (V+/+) and in vimentin-deficient mice (V-/-), the left common carotid artery (LCA) was ligated near its bifurcation, and 4...

The eco-design of complex industrial systems becomes a major issue for the concerned companies. Life Cycle Assessment (LCA) in particular is more adapted to “classical” products such as consumer goods. Performing LCA of such systems requires some thoughts to ensure significant results, for example concerning data granularity and quality. This article proposes a Life Cycle Assessment of an Alsto...

To understand the regulation of cell proliferation by tyrosine phosphorylation, characterization of protein tyrosine phosphatases (PTPase; protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48) is essential. The human genes LCA (leukocyte common antigen) and LAR encode putative receptor-linked PTPases. By using consensus sequence probes, two additional receptor-linked PTPase genes, DLAR and ...

The most common form of blindness at birth, Leber's congenital amaurosis (LCA), is inherited in an autosomal recessive fashion. Mutations in six different retina-specific genes, including a recently discovered gene, AIPL1, have been linked to LCA in humans. To understand the molecular basis of LCA caused by aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) mutations, and to elucidate...

Modern technology, together with an advanced economy, can provide a good or service in myriad ways, giving us choices on what to produce and how to produce it. To make those choices more intelligently, society needs to know not only the market price of each alternative, but the associated health and environmental consequences. A fair comparison requires evaluating the consequences across the wh...

We present a very simple algorithm for the Least Common Ancestor problem. We thus dispel the frequently held notion that an optimal LCA computation is unwieldy and unimplementable. Interestingly, this algorithm is a sequentialization of a previously known PRAM algorithm of Berkman, Breslauer, Galil, Schieber, and Vishkin [1].

Before embarking into the technicalities of the different algorithms for LCA, let us first agree on the terminology that we will be using throughout this article. Let there be a rooted tree T(E,V). A node x ∈ T is called an ancestor of a node y ∈ T if the path from the root of T to y goes through x. Also, a node v ∈ T is called to be a common ancestor of x and y if it is an ancestor of both x a...

α). Four different formulae are presented: a linear and a non-linear one for local damage, and a linear and a non-linear one for regional damage. The local linear function bears most resemblance to the IVAM formula for occupation: EDPlocal = 1 – (Socc / Sregion). The regional function includes the land use pattern already established in the region. The linear function is: EDPregion = dSlost / d...

Purpose: To evaluate the incidence of Leber’s Congenital Amaurosis (LCA) in low vision children referred to electrophysiology ward of Farabi Eye Hospital, and review the clinical features of disease and Electroretiongraphy (ERG) test values to confirm the diagnosis and severity of the disease in Iran. Design: Prospective observational case series Methods: Two-hundred and fifteen cases of low vi...

This chapter presents an overview of the current state of the art concerning the application of life cycle assessment (LCA) to assess and improve the environmental performance and sustainability of processes that use or are based on membrane technologies. A presentation of the LCA methodology is made, based on the current framework defined by the ISO Standard, focusing on the main aspects and h...