The aim of the paper is to investigate applicability of object-oriented software design patterns in the context of aspect-oriented design. The paper analyses which of the GoF 23 patterns have a meaning in this context and how they are affected by it. The main assumption is that there exist design patterns that solve software engineering paradigm independent design problems and that such pattern...

Estimation of Peak Flood Discharge (PFD) at a desired location on a river is important for planning, design and management of hydraulic structures. This can be achieved through Flood Frequency Analysis (FFA) by fitting of probability distributions to the series of annual maximum discharge data. In the present study, Exponential, Extreme Value Type-1, Extreme Value Type-2, Generalized Pareto and...

The importance of the use of Design Patterns in order to build reusable and wellstructured software has been eminent since these patterns have been formalized. Thus, it became desirable to be able to detect which design patterns are present in a software system. Knowing this information it is possible to make an evaluation on different aspects of the system. Though, it is a very difficult task ...

Design patterns add more reliability, flexibility and reusability to a software system. Taking advantage of design patterns is usually beneficial to software design and makes software development relatively easier. The state pattern proposed by GoF is not a determined design and can hardly be transformed into implementation code directly. It is disable to cope with sophisticated response event ...

Alkyl-lysophospholipids have been shown to possess antitumoral activity in animal and in human tumors. Among them, racemic 1-O-œtadecyl-2-O-methylglycero-3-phosphocholine (ET-18-OCH3) had an antimetastatic effect in experimental tu mors. We investigated the effect of ET-18-OCH3 on invasion of MO4 mouse fibrosarcoma cells and on cellular activities possibly related to invasion In vitro. Ten /¿...

Mutations in the PTPN11 gene, which encodes the protein tyrosine phosphatase SHP-2, causes Noonan syndrome (NS), an autosomal dominant disorder with pleomorphic developmental abnormalities. Certain germline and somatic PTPN11 mutations cause leukemias. Mutations have gain-of-function (GOF) effects with the commonest NS allele, N308D, being weaker than the leukemia-causing mutations. To study th...

BACKGROUND To investigate the contributions of CYP2C19 polymorphisms to the various clopidogrel responses tested by thrombelastography (TEG) in Chinese patients with the acute coronary syndrome (ACS). METHODS Patients were screened prospectively with ACS diagnose and were treated with clopidogrel and aspirin dual antiplatelet therapy. CYP2C19 loss of function (LOF) and gain of function (GOF) ...

In this paper we propose a different approach based on a spatio-temporal feature called the Spatio Temporal Regularity Flow (SPREF) to stabilize unwanted camera motions in a video, recognize the camera motion patterns between consecutive frames and Group of Frames(GOF) and track the motion of an object in a video with the background subtracted. The method for stabilization based on Camera Motio...

p53 and p63 are transcription factors -TFs- playing master roles in the DNA-damage response and in the development and maintenance of pluristratified epithelia, respectively. p53 mutations are common in epithelial tumors and HaCaT keratinocytes harbor two p53 alleles -H179Y and R282Q- with gain-of-function (GOF) activity. Indeed, functional inactivation of mutp53 affects the growth rate of HaCa...

Up until a few years ago, the dispersion parameter of Poisson-gamma models has been assumed to be invariant of the characteristics of the observations under study, but recent research in highway safety has shown that the dispersion parameter can potentially be dependent upon the covariates of the model. To account for this dependence, some researchers have reported that the dispersion parameter...