Intraperitoneal chemotherapy was explored in clinical trials as a promising strategy to improve the therapeutic effects of chemotherapy. In this work, we developed a biodegradable and injectable drug-delivery system by coencapsulation of docetaxel (Doc) and LL37 peptide polymeric nanoparticles (Doc+LL37 NPs) in a thermosensitive hydrogel system for colorectal peritoneal carcinoma therapy. First...

A polarization-selective uncooled infrared (IR) sensor was developed based on an asymmetric twodimensional plasmonic absorber (2-D PLA). The 2-D PLA has an Au-based 2-D periodic dimple structure, where photons can be manipulated by spoof surface plasmon polaritons. Asymmetry was introduced into the 2-D PLA to realize a polarization selective function. Numerical investigations demonstrate that a...

BACKGROUND The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the surrounding muscle tissue. METHODS Materials of pure PLA and PCL and their composites with flax fibers from genetically modified plants producing poly-3-hydroxybutyrate (PLA-tra...

Novel chitosan (CS)-coated poly(L-lactic acid) (PLA) fibers (CS–PLA) were prepared by reaction of an alkali and CS under heat treatment without a chemical binder. These treatments induced hydrolysis on the PLA surface, formation of ionic bonds between the carboxyl groups of the PLA surface and the amino groups of CS, and dehydration between the carboxyls and amines. The prepared fibers were cha...

BACKGROUND There are many combinations of treatments for pyogenic liver abscess (PLA). Different treatments are indicated for different clinical courses of PLA. AIMS To realize the current prevalence, clinical course, trend of treatment, and prognosis of pyogenic liver abscess (PLA) in Taiwan. METHODS We retrospectively reviewed the medical records of 126 patients with PLA. We divided them ...

We observe large-scale structures in hydrogels of poly(l-lactide)-poly(ethylene oxide)-poly(l-lactide) (PLLA-PEO-PLLA) ranging in size from a few hundred nanometers to several micrometers. These structures are apparent through both ultra-small angle scattering (USAS) techniques and confocal microscopy. The hydrogels showed power law scattering in the USAS regime, which is indicative of scatteri...

Three chitosan (CS), polyethylene glycol (PEG) and polylactic acid (PLA) nanocomposite systems containing SiO2 nanoparticles and water molecules were designed by molecular dynamics (MD) simulations to deliver pipobromane (PIP) anticancer drug in order to discover the most appropriate drug delivery system (DDS) in aqueous medium which was analogous to the human body. The density for the CS matri...

Software-Produktlinien erhalten im Automobilbereich zunehmende Bedeutung. Mit dem Produktlinienansatz (PLA) des SEI steht ein methodisches Rahmenwerk zu ihrer Realisierung zur Verfügung. Dieser Beitrag berichtet von Erfahrungen bei der Einführung von Software-Produktlinien nach dem PLA unter Anwendung des Vorgehensmusters What-to-Build. Im Anschluss werden Aktivitäten zur Anpassung des PLA an d...