Factor IX Chicago-2 and prothrombin Madrid were purified from patients with hemophilia B and congenital dysprothrombinemia. respectively. Each protein displays defects in zymogen activation secondary to the failure to cleave one of the sessile bonds whose cleavage is necessary for full coagulant activity. These proteins were isolated by immunoaffinity chromatography using conformation-specific ...

Synaptotagmins (Syts) constitute a large family of at least 16 members and individual Syt isoforms exhibit distinct Ca(2+)-binding properties and subcellular localization. It remains to be demonstrated whether multiple Syt isoforms can function independently or cooperatively on certain type of vesicle. In the current study, we have developed NPY-pHluorin to specifically assess exocytosis of lar...

Carbonic anhydrase IX (CA IX) is a transmembrane glycoprotein highly expressed in clear cell carcinoma of the kidney and in a wide variety of other human cancers. Its expression is largely under the control of intratumoral hypoxia and in some subtypes of renal cell carcinoma (RCC), by the presence of a defective version of the von Hippel Lindau (VHL) gene by which the HIF-1α factor is stabilize...

The bilrubin-IXalpha conjugates in bile and the activities of bilirubin-IX alpha--UDP-glycosyltransferases in liver and kidney were determined for ten species of mammals and for the chicken. 1. In the mammalian species, bilirubin-IX alpha glucuronide was the predominant bile pigment. Excretion of neutral glycosides was unimportant, except in the cat, the mouse, the rabbit and the dog, where glu...

In June 2022, the nation celebrated fiftieth anniversary of Title IX. This landmark legislation, part Education Amendments 1972, continues to have a huge impact, especially on colleges and universities, across efforts counter harassment discrimination based sex. A persistently controversial aspect IX is its application intercollegiate athletics. Prior IX, women had participated in athletics, wh...

For complex potentials V (x) = −(ix)3 − β(ix) − 2 β δ (ix) which are PT symmetric we show that in the β ≫ 1 strong coupling regime the low lying bound states almost coincide with harmonic oscillators whenever the spectrum remains real (this means, at all δ < δcritical(β) ≈ 1). PACS 03.65.Fd 03.65.Ca 03.65.Ge 03.65.Bz

Pembelajaran IPA memberikan peserta didik untuk mengkontruksi konsep melalui pengamatan secara penalaran ilmiah kemampuan berpiki kritis dan sikap kreatifitas. Salah satu pembelajaran yang membentuk tersebut dilakukan dengan menerapkan praktikum pembuatan handsanitizer alami menggunakan ekstrak Piper betle Citrus aurantifolia. Tujuan penelitian ini mengukur ketercapaian berpikir kreativitas kel...

The effect of two arginine-specific cysteine proteinases (gingipains R) from Porphyromonas gingivalis, an aetiological factor of adult periodontitis, on the activation of human factor IX was investigated in the presence of ethylene glycol, an activity enhancer of activated factor IX (factor IXa), with the use of a fluorogenic oligopeptide substrate. Each gingipain R rapidly activated factor IX ...

Spectrophotometric measurements of bilirubin-IX alpha in water and in aqueous/organic solvent mixtures at pH 10.0 as a function of bilirubin-IX alpha concentration (approx. 0.6--400 microM) are consistent with the formation of dimers (KD - 1.5 microM) in dilute (less than 10 microM) aqueous solution and further self-aggregation to multimers at higher concentrations. Added urea (to 10M) and incr...

1. The pneumococcal type IX polysaccharide (polysaccharide S IX) has been oxidized by sodium metaperiodate and reduced by sodium borohydride. Of the constituent monosaccharides, N-acetylglucosamine and N-acetylmannosamine remain unaltered, whereas 40% of the glucose and 90% of the glucuronic acid are oxidized. 2. The effect of oxidation and subsequent reduction on the precipitation of polysacch...