The chaperone (or chaperoning) system (CS) constitutes molecular chaperones, co-chaperones, and co-factors, interactors receptors, its canonical role is protein quality control. A malfunction of the CS may cause diseases, known as chaperonopathies. These are caused by qualitatively and/or quantitatively abnormal chaperones. Since ubiquitous, chaperonopathies systemic, affecting various tissues ...