نتایج جستجو برای: پروتئین bdnf

تعداد نتایج: 26807  

Journal: :The international journal of neuropsychopharmacology 2013
Maysa Sarhan Sophie Anne Pawlowski Florent Barthas Ipek Yalcin Jennifer Kaufling Hugues Dardente Venetia Zachariou Ralph Joseph Dileone Michel Barrot Pierre Veinante

In addition to its neurotrophic role, brain-derived neurotrophic factor (BDNF) is involved in a wide array of functions, including anxiety and pain. The central amygdaloid nucleus (CeA) contains a high concentration of BDNF in terminals, originating from the pontine parabrachial nucleus. Since the spino-parabrachio-amygdaloid neural pathway is known to convey nociceptive information, we hypothe...

2015
Anatoly Kreinin Serah Lisson Elimelech Nesher Jenny Schneider Josef Bergman Kamal Farhat Joseph Farah Flavio Lejbkowicz Gal Yadid Leon Raskin Igor Koman Albert Pinhasov Lin Lu

Though the role of brain derived neurotrophic factor (BDNF) as a marker for major depressive disorder (MDD) and antidepressant efficacy has been widely studied, the role of BDNF in distinct groups of patients remains unclear. We evaluated the diagnostic value of BDNF as a marker of disease severity measured by HAM-D scores and antidepressants efficacy among MDD patients. Fifty-one patients who ...

2014
Koji Tanaka Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Susumu Saigusa Mikio Kawamura Toshimitsu Araki Keiichi Uchida Yasuhiko Mohri Masato Kusunoki

Tropomyosin-related receptor kinase B (TrkB) signaling, stimulated by brain-derived neurotrophic factor (BDNF) ligand, promotes tumor progression, and is related to the poor prognosis of various malignancies. We sought to examine the clinical relevance of BDNF/TrkB expression in colorectal cancer (CRC) tissues, its prognostic value for CRC patients, and its therapeutic potential in vitro and in...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
J M Canals N Checa S Marco P Akerud A Michels E Pérez-Navarro E Tolosa E Arenas J Alberch

Changes in BDNF expression after different types of brain insults are related to neuroprotection, stimulation of sprouting, and synaptic reorganization. In the cerebral cortex, an autocrine-paracrine mechanism for BDNF has been proposed because the distribution patterns of BDNF and TrkB expression are almost identical. Moreover, cortical BDNF is anterogradely transported to the striatum, sugges...

Journal: :Molecular and cellular biology 2013
W Marcus Lambert Chong-Feng Xu Thomas A Neubert Moses V Chao Michael J Garabedian Freddy D Jeanneteau

Abnormal glucocorticoid and neurotrophin signaling has been implicated in numerous psychiatric disorders. However, the impact of neurotrophic signaling on glucocorticoid receptor (GR)-dependent gene expression is not understood. We therefore examined the impact of brain-derived neurotrophic factor (BDNF) signaling on GR transcriptional regulatory function by gene expression profiling in primary...

Journal: :Oncology reports 2006
Zhen Fan Yang David W Ho Chi Keung Lau Ka Ho Tam Chi Tat Lam Wan Ching Yu Ronnie T P Poon Sheung Tat Fan

The present study investigated the significance of the serum brain-derived neurotrophic factor (BDNF) and platelets in relation to the clinicopathological features of hepatocellular carcinoma (HCC) patients. Localization of the BDNF expression in human HCC tissues was performed by immunohistochemistry. The measurement of soluble BDNF in the serum was performed by enzyme-linked immunosorbent ass...

2014
Mei Jia Li Jian Xin Deng Narayan Chandra Paul Hyang Burm Lee Seung Hun Yu

Alternaria from different Allium plants was characterized by multilocus sequence analysis. Based on sequences of the β-tubulin (BT2b), the Alternaria allergen a1 (Alt a1), and the RNA polymerase II second largest subunit (RPB2) genes and phylogenetic data analysis, isolates were divided into two groups. The two groups were identical to representative isolates of A. porri (EGS48-147) and A. vanu...

Journal: :Neuron 1996
Serge Marty Benedikt Berninger Patrick Carroll Hans Thoenen

Gamma-Aminobutyric acid (GABA) switches from enhancing to repressing brain-derived neurotrophic factor (BDNF) mRNA synthesis during the maturation of hippocampal neurons in vitro. Interneurons do not produce BDNF themselves, but BDNF enhances their differentiation. Therefore, the question arose whether hippocampal interneurons regulate their phenotype by regulating BDNF expression and release f...

Journal: :Cell 2012
Yu-Wen A. Huang Claudia R. Ruiz Elizabeth C.H. Eyler Kathie Lin Mollie K. Meffert

Control of translation is a fundamental source of regulation in gene expression. The induction of protein synthesis by brain-derived neurotrophic factor (BDNF) critically contributes to enduring modifications of synaptic function, but how BDNF selectively affects only a minority of expressed mRNAs is poorly understood. We report that BDNF rapidly elevates Dicer, increasing mature miRNA levels a...

2007
Priit Pruunsild Anna Kazantseva1 Tamara Aid Kaia Palm Tõnis Timmusk

Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of neurotrophins, has central roles in the development, physiology, and pathology of the nervous system. We have elucidated the structure of the human BDNF gene, identified alternative transcripts, and studied their expression in adult human tissues and brain regions. In addition, the transcription initiation s...

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