SCL/tal is a putative oncogene originally identified through its involvement in the translocation t(1;14)(p32;qll) present in the leukemic cell line DU.528. Subsequent studies have shown an upstream deletion activating expression of SCLI tal to be one of the most common genetic lesions in T-cell acute lymphoblastic leukemia (T-ALL). The cDNA sequence of SCL/tal encodes a basic helix-loop-helix ...

Low-light image enhancement (LLE) remains challenging due to the unfavorable prevailing low-contrast and weak-visibility problems of single RGB images. In this paper, we respond intriguing learning-related question -- if leveraging both accessible unpaired over/underexposed images high-level semantic guidance, can improve performance cutting-edge LLE models? Here, propose an effective semantica...

The generation of platelets from megakaryocytes in the steady state is regulated by a variety of cytokines and transcription factors, including thrombopoietin (TPO), GATA-1, and NF-E2. Less is known about platelet production in the setting of stress thrombopoiesis, a pivotal event in the context of cytotoxic chemotherapy. Here we show in mice that the transcription factor Scl is critical for pl...

We developed rapid 24-h immunoblot assays for detecting autoantibodies to Scl 70 and Jo 1 antigens in serum. In comparative studies, we evaluated the analytical sensitivity of the immunoblot assays and commercial immunodiffusion assays for anti-Scl 70 and anti-Jo 1 autoantibodies with the use of positive control sera, and compared the frequencies of positive and negative results in a group of 1...

The orchestration of orienting behaviors requires the interaction of many cortical and subcortical areas, for example the superior colliculus (SC), as well as prefrontal areas responsible for top-down control. Orienting involves different behaviors, such as approach and avoidance. In the rat, these behaviors are at least partially mapped onto different SC subdomains, the lateral (SCl) and media...

AIM The aim of this study was to investigate the correlation of the Symptom Checklist-90-R (SCL-90-R) anxiety, depression, and somatization subscale scores with chronic low back pain. MATERIAL AND METHODS In this study, 75 patients admitted with the complaint of chronic low back pain (patient group) and 75 healthy persons (control group) were evaluated. SCL-90-R anxiety, depression, and somat...

The first costal scute (C 1) collected from 2, 749 hawksbill turtle (Eretmochelys imbricata) captured in Cuban waters in 1993 and 1994 were analyzed to determine their body size and age distributions. The C 1 width (C 1 W) was converted to the straight carapace length (SCL) using a formula, SCL = 4.3527 (C 1 W)0.8484, to examine its body size distribution. The SCL ranged from 51.3 to 96.1 cm wi...

BACKGROUND Lung transplantation (LTx) is a well-accepted treatment that can prolong survival of patients with advanced lung disease. OBJECTIVE To evaluate the association between serum cyclosporine level (SCL) pattern and mortality of LTx recipients. METHODS This retrospective cohort study included 1019 observations on 38 patients who underwent LTx in Masih Daneshvari Hospital from 2000 to ...

We describe the development of a human bone marrow (BM) culture system which allows study of the interaction of stromal cell lines (SCL) and highly purified hematopoietic progenitor cells. Normal BM stromal cells were electroporated with a plasmid containing the simian virus 40 (SV40) large T antigen (SV40 T Ag) under the control of a synthetic metallothionein promoter (MT4); this construct is ...