Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes. Previous researches have shown that Prospe...

This paper examines seven strategic factors that seem to make learning successful in networked collaboration. Through our literature review, it was found that there are at least seven strategic factors: deep thinking, more interaction, cognitive conflict resolution, adaptation over time, constructive use of technology, task coordination between media, and asynchrousness management. It is conclu...

Abstract Introduction In the United Kingdom (UK), 63% of adults are overweight,(1) costing NHS £6.1 billion/year. With public using digital technology over healthcare professionals (HCPs) for health advice, this warrants an investigation use in community pharmacy, given its previous successful use.(2) Aim To determine feasibility and perceptions a pharmacist (CP)-led weight management programme...

The study examined Israeli youths’ sense of group climate in online and offline educational settings, i.e., Instant Messaging (IM) groups organized by homeroom teachers for their respective students the physical classroom environment. Participants included 550 (152 boys, 398 girls), ages 10-18, who completed an survey. findings reveal that perceived to be more positive than IM which teacher is ...

One of the most famous collaborations in history was between Herbert Simon, Allen Newell, and J. C. Shaw who worked together over the phone. Simon was at Carnegie Institute of Technology in Pittsburgh and Newell and Shaw were at RAND in California. McCorduck (1979) wrote: “... Simon and Cliff Shaw seldom saw or spoke to each other. Newell carried out the middleman’s role, mostly by longdistance...

Se investigó la influencia de los patrones segregación sobre las transformaciones en estado sólido obtenidas a partir un tratamiento Q&P, realizado acero fundido con 0.52% C, aleado Cr, Mn y Si. El esquema tres tratamientos térmicos fue llevado cabo partiendo austenización total muestras 900°C, seguido por temple QT=250 una partición (PT)= 270°C, 300°C 350°C. Posteriormente, se llevó caract...

نوآوری در نتیجه ترکیبی از عناصر دانش سازمان‌ها ظاهر شده و به‌عنوان ماده خام اصلی برای نظر گرفته می‌شود. روش‌های سنتی دیگر اثربخش نیست به رویکردهای جدید همچو نیاز است. هدف پژوهش حاضر ، بررسی تأثیر قابلیت‌های مدیریت بر عملکرد با اثر میانجی باز است که 25 واحد‌ فناور مستقر «پارک فناوری پردیس» واقع شهر پردیس استان تهران نیمه دوم سال 1399 موردبررسی قرار گرفت. به‌منظور جمع‌آوری داده‌ها ابزار پرسشنامه ...