Ulixertinib (BVD-523) is an ERK1/2 kinase inhibitor with potent preclinical activity in BRAF- and RAS-mutant cell lines. In this multicenter phase I trial (NCT01781429), 135 patients were enrolled to an accelerated 3 + 3 dose-escalation cohort and six distinct dose-expansion cohorts. Dose escalation included 27 patients, dosed from 10 to 900 mg twice daily and established the recommended phase ...

We investigated the vestibulo-ocular reflex (VOR) during high-acceleration, yaw-axis, head rotations in 12 normals and 15 patients with vestibular loss (7 unilateral (UVD) and 8 bilateral (BVD)). We analyzed gaze stabilization within a 200ms window after head rotation began, using phase planes, which allowed simultaneous analysis of gaze velocity and gaze position. These 'gaze planes' revealed ...

BACKGROUND Bovine viral diarrhea (BVD) is an economically important cattle disease with a worldwide distribution. Detection and elimination of animals persistently infected (PI) with bovine viral diarrhea virus (BVDV) is essential for the control of BVD and eradication of BVDV. There are usually no pathognomonic clinical signs of BVDV infection. Diagnostic investigations therefore rely on labor...

We investigated the vestibulo-ocular reflex (VOR) during high-acceleration, yaw-axis, head rotations in 12 normals and 15 patients with vestibular loss [7 unilateral vestibular deficient (UVD) and 8 bilateral vestibular deficient (BVD)]. We analyzed gaze stabilization within a 200-ms window after head rotation began, using phase planes, which allowed simultaneous analysis of gaze velocity and g...

Profi tability of beef suckler herds is directly related to the number of calves reared per heifer or cow served annually. The economic consequences of high barren rates can, therefore, be very signifi cant, let alone the costs associated with the diagnosis and management of the problem causing poor fertility. In recent years, we have eradicated brucellosis, which used to be a major cause of re...

In this work we investigate the possible job-creation impact of artificial intelligence (AI) technologies, focusing on supply side, where development these technologies can be conceived as product innovations in upstream sectors. The empirical analysis is based a worldwide longitudinal sample (obtained by merging EPO PATSTAT and BvD-ORBIS databases) more than 3,500 front-runner companies that p...

Bovine viral diarrhea virus (BVDV) has a great economic impact on the United States cattle industry. The Academy of Veterinary Consultants, the American Association of Bovine Practitioners, and the National Cattlemen's Beef Association have called for the goal of BVDV control and eventual eradication in the U.S.A. One of the key factors in such efforts will be the detection of BVDV infections, ...