نتایج جستجو برای: هیستون دمتیلاز حاوی دمین jmjc
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Histone methylation is a dynamic process that participates in a diverse array of cellular processes and has been found to associate with cancer. Recently, several histone demethylases have been identified that catalyze the removal of methylation from histone H3 lysine residues. Through bioinformatic and biochemical analysis, we identified JARID1B as a H3K4 demethylase. Overexpression of JARID1B...
TNF-induced signaling mediates pleiotropic biological consequences including inflammation, immunity, cell proliferation and apoptosis. Misregulation of TNF signaling has been attributed as a major cause of chronic inflammatory diseases and cancer. Jumonji domain-containing protein 8 (JMJD8) belongs to the JmjC family. However, only part of the family members has been described as hydroxylase en...
Plants integrate responses to independent hormonal and environmental signals to survive adversity. In particular, the phytohormone gibberellin (GA) regulates a variety of developmental processes and stress responses. In this study, the Jumonji-C (JmjC) domain-containing gene JMJ524 was characterized in tomato. JMJ524 responded to circadian rhythms and was upregulated by GA treatment. Knockdown ...
The KDM4 subfamily of JmjC domain-containing demethylases mediates demethylation of histone H3K36me3/me2 and H3K9me3/me2. Several studies have shown that human and yeast KDM4 proteins bind to specific gene promoters and regulate gene expression. However, the genome-wide distribution of KDM4 proteins and the mechanism of genomic-targeting remain elusive. We have previously identified Drosophila ...
8. Bboomfield CD, Garson OM, Volin L, Knuutila 5, de Ia Chapelle A: t(l;3)(p36;q2l) in acute nonlymphocytic leukemia: A new cytogenetic-clinicopathologic association. Blood 66:1409, 1985 9. Viguie F, Marie J-P, Poler F, Bernadou A: Three cases of preleukemic myelodysplastic disorders with the same translocation t(l;3). Cancer Genet Cytogenet 19:213, 1986 10. Atichartakarn V, Punyammalee B, Wong...
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins co...
Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain-containing family of demethylases comprises 27 members that target mono-, di-, and trimethylated lysine residues of histone (or nonhistone) proteins. To evaluate their role in regulation of hematopoietic stem cell (HSC) behavior, we performed an in vivo RNAi-based fun...
چکیده: اساطیر ومفاهیم اسطوره ای،به دلیل عجین شدن بن مایه های کم وپیش آن با ناخودآگاه جمعی،در نزد شاعرانی که دارای نگرش های فلسفی،اجتماعی یا فکری وفرهنگی خاصی هستند،نمود بیشتری دارد.خلیل حاوی از جمله این شاعران است که حجم وسیعی از اسطوره ها رادر اشعار خود به کار برده است.اودر جامعه ای می زیست که جمود،جهل ،نادانی واستبداد و استعمار پذیری ازمهمترین مولفه های آن بود.او در این اوضاع نابسامان اجتماع...
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