In mammalian cells, nontranslating messenger RNAs (mRNAs) are concentrated in different cytoplasmic foci, such as processing bodies (PBs) and stress granules (SGs), where they are either degraded or stored. In the present study, we have thoroughly characterized cytoplasmic foci, hereafter called AGs for ALK granules that form in transformed cells expressing the constitutively active anaplastic ...

In this paper, we present a new denotational semantics of attribute grammars (AGs) by using Cardelli's record calculus. This new denotational semantics is simple, natural and structure-oriented. AGs have been considered useful in describing interactive programming environments as well as in specifying the semantics of programming languages. Using AGs, interactive programming environments are of...

introduction: regarding chronic nature of epilepsy and its side effects and to access the effective treatment procedures, herbal medicine has received remarkable interest. the aim of this study was to determine the anticonvulsant effects of hydro-alcoholic extract of anethum graveolens seed on pentylenetetrazol (ptz) -induced seizure in male mice. methods: fifty-six albino male mice were divide...

The present article aims at modeling a day-ahead local electricity market (DA LEM) for transactive energy trading the distribution level. In this regard, wide range of distributed resources (DERs) in form multiple aggregators (AGs) participates DA LEM order to trade with system operator (DSO), market. On other hand, DSO, as owner system, has responsibility procure required its customers respect...

In the last few years it has been shown that the humoral immune response in cancer patients is a rich source of putative cancer vaccine candidates. To fully explore the complex information present within the Ab repertoire of cancer patients, we have applied a method, serological Ag selection, to molecularly define tumor Ags recognized by the humoral immune response in colorectal cancer (CRC). F...

The ‘dear enemy phenomenon’ (DEP) is a form of neighbour–stranger discrimination in which resident territorial individuals respond less agonistically to intrusions by known neighbouring conspecifics than they do to strangers. We tested philopatric female yellow-bellied marmots (Marmota flaviventris) for the presence of DEP. We hypothesized that dominant females discriminated between the anal gl...

Aptamers have emerged as promising molecular probes for disease diagnosis and therapy. In the present study, the entire live cell-SELEX method was used to generate gastric cancer cell‑specific aptamers. Human gastric carcinoma AGS cells were used as target cells for positive selections and human normal gastric epithelial GES-1 cells as the negative cells for counter selections. The selection pr...

BACKGROUND Alagille syndrome (AGS) is a dominantly inherited multisystem disorder involving the liver, heart, eyes, face, and skeleton, caused by mutations in Jagged1. Intracranial bleeding is a recognized complication and cause of mortality in AGS. There are multiple case reports of intracranial vessel abnormalities and other vascular anomalies in AGS. The objective of this study was to charac...

Molecular mimicry manifests antagonistically with respect to the specificity of immune recognition. However, it often occurs because different Ags share surface topologies in terms of shape or chemical nature. It also occurs when a flexible paratope accommodates dissimilar Ags by adjusting structural features according to the antigenic epitopes or differential positioning in the Ag combining si...