Invariant natural killer T (iNKT) cells are an important source of both T helper type 1 (Th1) and Th2 cytokines, through which they can exert beneficial, as well as deleterious, effects in a variety of inflammatory diseases. This functional heterogeneity raises the question of how far phenotypically distinct subpopulations are responsible for such contrasting activities. In this study, we ident...

Foxn1 is essential for thymic organogenesis and T lymphopoiesis. Whereas reduced Foxn1 expression results in a decline in T lymphopoiesis, overexpression of Foxn1 in the thymus of a transgenic mouse model (Foxn1Tg) attenuates the age-associated decline in T lymphopoiesis. T lymphopoiesis begins with early T cell progenitors (ETP), derived from multipotent progenitors (MPP) in the bone marrow (B...

Previous research indicates that abnormal attention-emotion interactions are related to symptom presentation in individuals with schizophrenia. However, the individual components of attention responsible for this dysfunction are unclear. In the current study we examined the possibility that schizophrenia patients with higher levels of negative symptoms (HI-NEG: n=14) have greater difficulty dis...

One of the diagnostic criteria of essential thrombocythemia laboratory characteristics, except for a significant increased patients’ age and decreased polymorphonuclear cell count (ET) is the absence of the Philadelphia chromosome (Phneg). On the molecular level, Ph-neg ET patients may carry in the BCR-ABL positive group. During a median follow-up of 20 and 22.5 months for the BCR-ABL negative ...

Individuals higher in social anxiety report more impaired friendship quality, which past research suggests may stem from constrained warmth. We examined three motivations for constrained warmth in friendships and determined how these motivations related to social anxiety and friendship impairment. To do so, we assessed the psychometric properties of the Favor Scale (FS), which measures an indiv...

The Talk Test (TT) is a simple technique for prescribing exercise training intensity, based on the ability to ‘speak comfortably’ after reciting a standard speech provoking stimulus. This study compares the length of the speech provoking stimulus on power output (PO) at standard TT speech comfort markers: last positive (LP), equivocal (EQ), negative (NEG), in relation to objective markers of ex...

AIMS Induced pluripotent stem cell (iPSC)-derived cardiovascular progenitor cells represent a suitable autologous cell source for myocardial regeneration as they have the capability to form myocardial cells and to contribute to revascularization. As a first proof of concept we evaluated the potential of a murine iPSC-derived cardiovascular progenitor population, which expresses the surface mark...

In the presence of price distortions, cost-benefit analysis must include changes in the deadweight loss in addition to the direct benefits and costs to transportation users and nonusers. Advances in new economic geography (NEG) have highlighted the importance of price distortions associated with imperfect competition. This paper reviews recent contributions to cost-benefit analysis in NEG model...