The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge Coenzyme Q10’s role health disease. Classical antioxidant bioenergetic functions of coenzyme have been taken into consideration, as well novel mechanisms action involving redox-regulated activation molecular pathways associated with anti-inflammatory activities. Ca...

Introduction Conclusions References

Background Non-essential nutrients, L-carnitine (carnitine) and coenzyme Q10 (CoQ10) have attracted much attention as supplements for anti-aging and improvement of metabolism. Although the levels of carnitine and CoQ10 in the body decrease with advancing age, dietitians do not consider intakes of these nutrients when they plan food prescription or menu for elderly people. In addition, there are...

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment *Carlos Perez-Sanchez,1 *Patricia Ruiz-Limon,1 Maria Angeles Aguirre,1 Maria Laura Bertolaccini,2 Munther A. Khamashta,3 Antonio Rodriguez-Ariza,1 Pedro Segui,1 Eduardo Collantes-Estevez,1 Nuria Barbarroja,4 Husam Khraiwesh,5 Jose Antonio Gonzalez-Reyes,5...

The spatial representations of response characteristics to acoustic stimuli within the ventral primary auditory cortex (AI) and the second auditory cortical field (AII) were mapped in the left hemispheres of 14 anesthetized adult cats using closely spaced (200-500 micron) microelectrode penetrations to record cortical responses from small cell clusters. Responses were activated by 200-ms tone b...

Introduction: Myocardial infarction (MI) has a deleterious effect on quality of life (QoL), which can affect cardiac prognosis after MI. Thus, new strategies have to be identified for improving the QoL. To our knowledge, no studies have been conducted on the impact of therapeutic lifestyle change (TLC) diet and L-carnitine plus Q10 supplementation on QoL after MI. Methods: The study aimed to me...