Thomas and colleagues (pp. 1122-1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these post-transcriptional processes during normal fetal muscle development. Finally, they generate and characterize a mouse model of CDM that lacks all three Muscle...

the clean development mechanism (cdm) under the kyoto protocol is the only mechanism with dual objectives in which non-annex b countries of the protocol, particular developing countries, have the ability to participate in it. certified emission reduction (cer) units resulting from the activities of the cdm projects are the tradable units that usually traded by the participants in these projects...

Climate change is one of the most significant challenges to sustainable development facing the international community. Increased attention has been given by industries and governments from both industrialized and developing countries to reduce greenhouse gas (GHG) emissions through the clean development mechanism (CDM), one of the Kyoto Protocol’s (KP) flexible mechanisms. China is the biggest...

Cytosine DNA methylation (CDM) is a stable epigenetic modification to the genome and a widespread regulatory process in living organisms that involves multicomponent molecular machines. Genome-wide cytosine methylation patterning participates in the epigenetic reprogramming of a cell, suggesting that the biological information contained within methylation positions may be amenable to decoding. ...

We test semi-analytic models for galaxy formation with accurate kinematic data of damped Lyα protogalaxies presented in a companion paper (Wolfe & Prochaska 2000). The models envisage centrifugally supported exponential disks at the centers of dark matter halos which are filled with ionized gas undergoing radial infall to the disks. The halo masses are drawn from cross-section weighted mass dis...

The supersymmetric extension to the Standard Model offers a promising cold dark matter candidate, the lightest neutralino. I will review the phenomenological and cosmological constraints on the supersymmetric parameter space and discuss the prospects for the detection of this candidate in both accelerator and direct detection searches.

ly we know that 〈A 〉 always exists since 〈A 〉 = ⋂ {H ⊆ G | A ⊆ H subgroup } But computationally this is useless: we already have to know all subgroups (containing A) to compute the intersection. Even if G is finite and relatively small, there is no hope to build an algorithm on this characterization. Also note that 〈A 〉 is one of the H’s on the right hand side (impredicative definition). So how...

Springback is one of the most common and important issues in metal forming area. Due to the fact that springback depends on a variety of parameters, it is hard to predict. Hence, in this paper, the effect of continuum damage mechanics (CDM) on springback was investigated based on the Lemaitre isotropic unified damage law. Swift’s hardening law was employed to describe isotropic hardening behavi...