Recent studies have shown the expression of a stem cell marker protein, nestin, in nascent blood vessels in nestin-driven green fluorescent protein (ND-GFP) transgenic nude mice. In the present study, we visualized tumor angiogenesis and evaluated the antiangiogenic efficacy of CPT-11 in ND-GFP nude mice using dual-color fluorescence imaging. We orthotopically implanted ND-GFP nude mice with th...

In 34 tumors of different origin 50 comparisons between the tumor response in the patients and in nude mice were performed. Combination chemotherapy was more successful than single agent chemotherapy. Out of the 25 combinations given, 9 (36%) effected a remission in comparison to 4 out of 25 (16%) after single agent chemotherapy. 13 patients got a remission which was found in 12 cases in the nu...

Athymic B A L B / c ( N u / N u ) mice died at 7-13 days after inoculation ( D A I ) of P lasmodium berghei NK65 , whereas their heterozygous ( N u / + ) l i t termates died at 7-8 D A I . N u d e ( N u / N u ) mice , reconsti tuted w i th 2 x 10 7 splenocytes f r o m unin­ fected heterozygous ( N u / + ) l i t termates at 20 days before parasite inoculation ( D B I ) , died about 2 days earl i...

Faces and bodies convey important information for the identification of potential sexual partners, yet clothing typically covers many of the bodily cues relevant for mating and reproduction. In this eye tracking study, we assessed how men and women viewed nude and clothed, same and opposite gender human figures. We found that participants inspected the nude bodies more thoroughly. First fixatio...

The goal of this study was to investigate the normal MRI appearance of lymphoid organs in immuno-competent and immuno-deficient mice commonly used in research. Four mice from each of four different mouse strains (nude, NOG, C57BL/6, CB-17 SCID (SCID)) were imaged weekly for one month. Images were acquired with a 3D balanced steady state free precession (bSSFP) sequence. The volume of the lymph ...

OBJECTIVE This study used functional magnetic resonance imaging (fMRI) to contrast the differential brain activation patterns in response to visual stimulation with both male and female erotic nude pictures in male-to-female (MTF) transsexuals who underwent a sex reassignment surgery. MATERIALS AND METHODS A total of nine healthy MTF transsexuals after a sex reassignment surgery underwent fMR...

Human pituitary adenoma tissues were not tumorigenic in the hormonally manipulated nude mouse. Mouse fibroblast cells (C3H 10T1/2) also did not form tumors when inoculated alone into nude mice. When these two tissues were cocultured and coinoculated into nude mice however, the majority of inocula developed progressively enlarging tumors which could be established in tissue culture and passaged ...

BACKGROUND AND OBJECTIVE Methylseleninic acid (MSA) is an artificially developed selenium compound. It has been proven that MSA could inhibit growth and metastasis on many tumor cells. This study investigated whether MSA has an impact on the growth and metastasis of L9981-Luc lung cancer transplanted model in nude mice or not. METHODS A transplantated tumor model was established in nude mice....

Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. Mixing experiments using different numbers of nude bone marrow...