OBJECTIVE The NOD mouse strain has been widely used to investigate the pathology and genetic susceptibility for type 1 diabetes. Induced pluripotent stem cells (iPSCs) derived from this unique mouse strain would enable new strategies for investigating type 1 diabetes pathogenesis and potential therapeutic targets. The objective of this study was to determine whether somatic fibroblasts from NOD...

In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher f...

Organizational mistakes and accidents have a long history in practice been studied extensively the engineering organizational literature. One of primary causes persistent error is existence deviance; i.e., behavior violating norms. We examined behaviors motivations project team members situations where deviant had accepted normalized as part operations. used NVivo content analysis to classify n...

زمینه و هدف: یکی از راهکارهای مناسب برای محافظت در برابر تأثیرات نامطلوب فشار اکسایشی ناشی تمرینات ورزشی طولانی‌مدت شدید، به‌کارگیری تدابیر تغذیه‌ای سالم استفاده مکمل‌های ضداکسایشی است. هدف این پژوهش بررسی اثر مصرف عصارة عناب طی دو نوع تمرین تناوبی استقامتی شدید بر شاخص‌های بافت کبد موش‌های صحرایی نابالغ نر بود.مواد روش‌ها: 72 سر موش نژاد ویستار با سن 22 روز میانگین وزنی 475/7 ± 64/60 گرم پس وز...

Catharina Alam The influence of diet and microbes on colonic immune regulation and their implications on type 1 diabetes Department of Medical Microbiology and Immunology, University of Turku Annales Universitatis Turkuensis Turku, Finland Dietary and microbial factors are thought to contribute to the rapidly increasing prevalence of T1D in many countries worldwide. The impact of these factors ...

The legume-rhizobium symbiosis is initiated through the activation of the Nodulation (Nod) factor-signaling cascade, leading to a rapid reprogramming of host cell developmental pathways. In this work, we combine transcriptome sequencing with molecular genetics and network analysis to quantify and categorize the transcriptional changes occurring in roots of Medicago truncatula from minutes to da...

The nonobese diabetic (NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control strain B10.Q by using the speed congenic breeding strategy, resulting in three congenic strains: B10.Q.Nss1, B10.Q.Nss1/Idd5 heterozygous and B10.Q.Nss1/Idd5 homozygous. We investigated the effects of the Ns...

Autoimmune diabetes is characterized by an early mononuclear infiltration of pancreatic islets and later selective autoimmune destruction of insulin-producing beta cells. Lymphocyte homing receptors have been considered candidate targets to prevent autoimmune diabetes. L-selectin (CD62L) is an adhesion molecule highly expressed in naive T and B cells. It has been reported that blocking L-select...

OBJECTIVE Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and humans. This study aimed to determine whether suppression of G6p2 gene expression might therefore prevent or delay disease progression. RESEARCH DESIGN AND METHODS G6pc2(-/-) mi...

We previously showed that applying 10(-6) M of the cytokinin 6-benzylaminopurine (BAP) to uninoculated roots of Masym3, a Nod(-)Myc(-)Melilotus alba (Desr.) mutant, resulted in the accumulation of MaENOD40 transcripts to levels similar to BAP-treated wild-type roots. In contrast, inoculation with a Nod(-)S. meliloti mutant expressing the trans-zeatin synthase gene of Agrobacterium tumefaciens (...