We continue our study of significance tests. In these notes we will introduce two new tests: one-sample t-tests and two-sample t-tests. You should pay careful attention to the fact that every test makes some assumptions about the data – often that is drawn from a normal distribution. You should also notice that all the tests follow the same pattern. It is just the computation of the test statis...

NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as (19)F spectra are typically very sparse. Here, we...

Aziridines can undergo a range of ring-opening reactions with nucleophiles. The regio- and stereochemistry of the products depend on the substituents on the aziridine. Aziridine ring-opening reactions have rarely been used in radiosynthesis. Herein we report the ring opening of activated aziridine-2-carboxylates with [(18)F]fluoride. The aziridine was activated for nucleophilic attack by substi...

Venkatapuram Seenu Reddy, Sumanth D. Prabhu, Srinivas Mummidi, Anthony J. Valente, Balachandar Venkatesan, Prakashsrinivasan Shanmugam, Patrice Delafontaine, and Bysani Chandrasekar Cardiothoracic Surgery, University of Texas Health Science Center, San Antonio, Texas; Institute of Molecular Cardiology, Department of Medicine, University of Louisville, and Medical Service, Louisville Veterans Af...

BACKGROUND One strategy for improving family planning (FP) uptake at the community level is the use of performance-based incentives (PBIs), which offer community distributors financial incentives to recruit more users of FP. This article examines the use of PBIs in community-based FP programmes via a literature search of the peer-reviewed and grey literature conducted in April 2013. RESULTS A...

A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. However, unlike so...