This review covers from the basic principles of Raman spectroscopy to the advanced technique of surface enhanced Raman Scattering (SERS) spectroscopy. After briefly going through the description of Raman and introduction of the development of SERS, the article will focus on the “hotspot” of the current research work on SERS – single molecule spectroscopy. We will see later that “hotspot” is als...

Optical excitation of coupled plasmonic nanoparticles supports intense localized electromagnetic "hot-spots" which enable a variety of surface enhanced spectroscopies with the best known example being surface enhanced Raman scattering (SERS), currently of great interest for sensing applications. In this study, we present a novel SERS and electrical dual transduction chemical sensor based on gas...

Label-free Surface-enhanced Raman scattering (LF-SERS) spectroscopy of biofluids (e.g. blood, urine) has recently raised interest for its potential in the field of diagnostics [1]. Being portable and having a fast response, SERS is particularly appealing for point-of-care applications. LF-SERS spectra of biofluids can be viewed as "partial metabolic fingerprints" due to a subset of metabolites ...

Over the last few decades, benefitting from the sufficient sensitivity, high specificity, nondestructive, and rapid detection capability of the surface-enhanced Raman scattering (SERS) technique, numerous nanostructures have been elaborately designed and successfully synthesized as high-performance SERS substrates, which have been extensively exploited for the identification of chemical and bio...

After its discovery more than 30 years ago, surface-enhanced Raman spectroscopy (SERS) was expected to have major impact as a sensitive analytical technique and tool for fundamental studies of surface species. Unfortunately, the lack of reliable and reproducible fabrication methods limited its applicability. In recent years, SERS has enjoyed a renaissance, and there is renewed interest in both ...

We present the results of an investigation of surface-enhanced Raman scattering (SERS) by optical phonons in colloidal CdSe nanocrystals (NCs) homogeneously deposited on both arrays of Au nanoclusters and Au dimers using the Langmuir-Blodgett technique. The coverage of the deposited NCs was less than one monolayer, as determined by transmission and scanning electron microscopy. SERS by optical ...