OBJECTIVE Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF). We evaluated the balance between histone deacetytlase (HDAC) and histone acetyltransferase (HAT) in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) compared to healthy controls (HC) and determined the influence of HDAC inhibitors (trichostatin A -TS...

The half-a-tetratricopeptide repeat (HAT) motif is a helical repeat motif found in proteins that influence various aspects of RNA metabolism, including rRNA biogenesis, RNA splicing, and polyadenylation. This functional association with RNA suggested that HAT repeat tracts might bind RNA. However, RNA binding activity has not been reported for any HAT repeat tract, and recent literature has emp...

Human African trypanosomiasis (HAT) is a fatal if untreated fly-borne neuroinflammatory disease caused by protozoa of the species Trypanosoma brucei (T.b.). The increasing trend of HAT cases has been reversed, but according to WHO experts, new epidemics of this disease could appear. In addition, HAT is still a considerable burden for life quality and economy in 36 sub-Saharan Africa countries w...

A team of n players enters a game room, and each player is fitted with a hat, which is either red or green. A player can see the other players’ hat colors, but hot his own. Each player is then asked to make a declarations, which must be one of the statements “my hat is red,” “my hat is green,” or “I pass.” All the players must declare simultaneously, and no communication is allowed between them...

Unmanned aerial systems, advanced cockpits, and air traffic management are all seeing dramatic increases in automation. However, while automation may take on some tasks previously performed by humans, humans will still be required to remain in the system for the foreseeable future. The collaboration between humans and these increasingly autonomous systems will begin to resemble cooperation betw...

هدف اصلی این پژوهش ارائه چارچوبی برای ارزیابی عملکرد شرکت بهره‌­برداری قطار شهری مشهد بر مبنای کارت امتیازی متوازن و تکنیک تصمیم‌­گیری چندمعیاره (بهترین ـ بدترین فازی) است. حاضر از نظر هدف، کاربردی روش، کمّی اسنادی جمع‌­آوری داده‌های کیفی اساس 15 خبره در طی مقطع زمانی بین سال­‌های 1396 تا 1398 صورت پذیرفت. 9 معیار منظر مالی، 16 مشتریان، 8 فرایند داخلی 14 رشد توسعه یادگیری طریق اسناد پژوهش­‌های پ...

OBJECTIVE To review the geography and history of sleeping sickness (Human African trypanosomiasis; HAT) over the past 100 years in West Africa, to identify priority areas for sleeping sickness surveillance and areas where HAT no longer seems active. METHOD History and geography of HAT were summarized based on a review of old reports and recent publications and on recent results obtained from ...

Human African trypanosomiasis (HAT) is a disease caused by Kinetoplastid infection. Serological tests are useful for epidemiological surveillance. The aim of this study was to develop a multiplex serological assay for HAT to assess the diagnostic value of selected HAT antigens for sero-epidemiological surveillance. We cloned loci encoding eight antigens from Trypanosoma brucei gambiense, expres...

The effects of an atomic hydrogen (Hat ) pretreatment of the catalyst layer on the low tem‐ perature growth of single‐walled carbon nanotubes (SWCNTs) have been investigated using a modified catalytic chemical vapor deposition system. Well‐defined and isolated individual Fe nanoparticles as a catalyst are successfully formed on the defects wit...

AIM Mesenchymal stem cells (MSCs) isolated from human bone marrow (hBM) and adipose tissue (hAT) are perceived as attractive sources of stem cells for cell therapy. The aim of this study was to compare MSCs from hBM and hAT for their immunocytochemistry staining and resistance to in vitro apoptosis. METHODS In our study, we investigated the antiapoptotic ability of these MSCs toward oxidative...