background: melatonin, a reactive oxygen species (ros) scavenger and an antioxidant, has been shown that can inhibit apoptosis. administration of melatonin may improve embryo development in assisted reproductive technology (art). objective: the aim of this study was to evaluate the role of melatonin in inhibition of spontaneous and induced apoptosis by tumor necrosis factor alph (tnf-α) and act...

background: use of hormone replacement therapy (hrt) may increase the risk of adult-onset asthma in women. various in vitro studies have reported that estradiol stimulates human mast cell lines causing release of allergic mediators which was not observed in estrogen receptor-alpha (er-alpha) knockout mice. thus, estrogen might be a key element in occurrence of asthma. in the present study, we p...

background and aims. the role of cytokines in the immunopathogenesis of oral lichen planus (olp) has received much attention. the aim of this study was to evaluate the serum levels of tnf-α and tgf-β in patients with olp in an iranian population. materials and methods. thirty-two patients with olp and 32 age-matched healthy volunteers as a control group were included in this study. serum tests ...

مقدمه افزایش سن، سندروم متابولیک و عوامل التهابی از عوامل موثر در کاهش حجم مغز و افت عملکرد شناختی می باشد. هدف از این تحقیق بررسی اثرگذاری 12 هفته تمرین هوازی با شدت متوسط بر bdnf و tnf-α زنان 50-65 ساله مبتلا به سندروم متابولیک می باشد. روش کار این مطالعه به روش نیم تجربی و از نوع کاربردی با طرح پیش آزمون – پس آزمون و گروه کنترل در شهر زنجان درسال 1394 انجام شده است. 24 زن مبتلا به سندروم متا...

melanocortin-1 (mc1) receptor is an attractive melanoma-specific target for the development of α-msh peptide based imaging and therapeutic agents. in this work a new lactam bridge α-msh analogue was synthesized and radiolabeled with 99mtc via hynic chelator and tricine as co-ligand. also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

thermoplastic starch (tps) materials present several advantages to the plastic industry andwhen blended with other materials they can exhibit improved mechanical and moisturesensitivity properties compared to pure tps materials. further investigations on tps: pvablends are of particular interest due to their excellent compatibility and improved properties suchas tensile strength, elongation, to...

background: in this study, the pilot production of aerobic bioreactor tropical theileriosis vaccine was optimized with the aim of immunological assays for further mass production. methods: we have shown earlier the delayed type hypersensitivity (dth) assay could be used for evaluating the immunity and memory cells against specific theileria antigen in vaccinated animals. in addition, tnf-α is t...

the thermal denaturation of α-amylase from bacillus amyloliquefaciens has been investigated in the presence and absence of sodium dodecyl sulphate (sds) over the temperature range (293-373) k in 20 mm sodium phosphate buffer, ph 6.9, using temperature scanning spectroscopy. the presence of sds caused the destabilization of α-amylase resulting in a decrease in the temperature of unfolding with a...

this work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1h-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-fe2o3 nanoparticles. eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily availa...

α-galycoceramide (α-galcer) or the common name of krn7000 is an α-gelasphin derivative. the α-galcer structure consists of a galactose combined with a ceramide in an α-configuration. social isolation (si) has been linked with enhanced inflammation, through modifications in transcriptional pathways linked with glucocorticoid, to stress. our hypothesis is to investigate mediatory role of glucocor...