Introduction: Leishmania tarentolae (L. tarentolae) is a nonpathogenic species of Leishmania genus that can be used as an expression system to produce immunogenic proteins or epitopes in vivo acting as an efficient and safe recombinant live vector in vaccinology. Cysteine proteases (CPs) are one group of Family C1 peptidases in Leishmania that are important for survival of the parasite within...

The dose-limiting factor of cyclophosphamide (CPA) is cardiac toxicity.1 The maximum tolerated dose of CPA is approximately 200 mg/kg and fatal cardiac toxicity is rare at lower doses.1 However, two groups reported that same-day administration of cytarabine (Ara-C) and CPA increased the incidence of fatal cardiac toxicity.2,3 On the other hand, in the BEAC regimen, one of the most popular prepa...

Since the prognosis of advanced biliary tract cancer (aBTC) still remains very poor, new therapeutic approaches, including immunotherapies, need to be developed. In the current study, we conducted an open-label randomized phase II study to test whether low dose cyclophosphamide (CPA) could improve antigen-specific immune responses and clinical efficacy of personalized peptide vaccination (PPV) ...

BACKGROUND Some comprehensive cancer centers in industrialized countries have reported improved outcomes in their cardiopulmonary arrest (CPA) patients. Little is known about the outcomes and predictors of CPA in cancer centers in other parts of the world. The objective of this study was to examine the predictors of CPA outcome in a comprehensive cancer center closed medical-surgical intensive ...

Child physical abuse (CPA) is a pervasive societal problem with serious outcomes. Understanding CPA risk factors necessary to identify those at for perpetration and inform efforts prevent the occurrence of CPA. The present study provides an updated review conceptual models CPA, model-related factors, meta-analytic found in cross-sectional, case-controlled studies. yielded >70 explanatory from w...

Cyclophosphamide (CPA) and ifosfamide (IFA) are widely used anticancer prodrugs that are bioactivated in the liver by specific cytochrome P450 enzymes (CYPs). The therapeutic activity of these antitumor agents can be compromised by a low therapeutic index that is, in part, due to the systemic distribution of activated drug metabolites. Here, recombinant retroviruses were used to deliver six dif...

Cardiopulmonary cerebral resuscitation for cardiopulmonary arrest (CPA) is often unsuccessful. Therefore, any method that could decrease the significant mortality associated with CPA would be valuable. Current pharmacologic management of CPA involves the use of epinephrine for increased cardiac output and systemic vasoconstriction; however, this agent is associated with a significant number of ...

A 61-year-old man with 5-fluorouracil (5-FU) chemotherapy suffered a cardiopulmonary arrest (CPA). The electrocardiogram showed changes consistent with myocardial infarction only during CPA that was normalized 30 minutes after cardiopulmonary resuscitation. Coronary angiography showed no significant stenosis. We suspected the cause of CPA to be vasospastic angina due to 5-FU and administered Be...

A highly aggressive human CALLA+Cp+ pre-B acute lymphoblastic leukemia (ALL) cell line (NALM-6-UM1) causes disseminated and invariably fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). We used this SClD mouse model of human pre-B ALL to evaluate and compare, in a total of 434 SClD mice, the antileukemic efficacy of 843 (anti-CD19)-pokeweed antiviral protein (PAP) immuno...

Objective To retrospectively evaluate the impact of pedal arch quality on tissue loss and time to healing in diabetic patients with foot wounds undergoing infrainguinal endovascular revascularization. Materials and Methods Between January 2014 and June 2015, 137 consecutive diabetic patients with foot wounds underwent infrainguinal endovascular revascularization (femoro-popliteal or below-the...