PURPOSE The aim of this work was to study changes in the tumor microenvironment early after an antiangiogenic treatment using thalidomide (a promising angiogenesis inhibitor in a variety of cancers), with special focus on a possible "normalization" of the tumor vasculature that could be exploited to improve radiotherapy. EXPERIMENTAL DESIGN Tumor oxygenation, perfusion, permeability, intersti...

Background. Inflammatory Fibroid Polyp (IFP) of the colon is an exceedingly rare condition. Since 1952 till now only 32 cases have been reported worldwide of which only 5 were giant (>4 cm) polyps mostly found in the caecum (15 cases) with only 3 in the descending colon. Case Presentation. A 36-year-old female with no previous illness presented to the emergency unit with an acute onset pain ove...

Most solid malignancies display interstitial hypertension and a poor uptake of anticancer drugs. Platelet-derived growth factor (PDGF) and the cognate tyrosine kinase receptors are expressed in many tumors. Signaling through PDGFbeta receptors was shown recently to increase interstitial fluid pressure (IFP) in dermis after anaphylaxis-induced lowering of IFP. In this study, we show that treatme...

Abstract Graph learning is being increasingly applied to image clustering reveal intra-class and inter-class relationships in data. However, existing graph learning-based focuses on grouping images under a single view, which under-utilises the information provided by To address that, we propose self-supervised multi-view technique contrastive heterogeneous learning. Our method computes affinity...

A new imidazolate-4-amide-5-imidate based MOF, IFP-7, is generated, having flexible methoxy groups, which act as molecular gates for guest molecules. This allows highly selective CO2 sorption over N2 and CH4 gases.

the gastric inflammatory fibroid polyp (ifp) is a rare benign tumor of unknown etiology that is localized mainly in the antrum and presents endoscopically as submucosal mass. the lesion manifests as abdominal pain, weight loss, bleeding, dyspeptic symptoms, and iron deficiency anemia. we report a case of gastric ifp presented with microcytic anaemia, dyspepsia, malena and weight loss. endoscopy...

Use of insulin in the treatment of type 2 diabetics may vary among different countries from 5% to 50%. The validity of this evaluation may depend on the diabetes type classification of adult insulin-treated patients (ITP). An attempt at such evaluation was made by using data of the Ukrainian Diabetes Mellitus Register (102,580 ITP aged ≥30). ITP were stratified into subgroups according to age a...

An Optimization Strategy Based on the Maximization of Matching-Targets’ Probability for Unevaluated Results— TheMaximization ofMatching-Targets’ Probability forUnevaluated Results (MMTPUR), technique presented in this paper, is based on the classical probabilistic optimization framework. The numerical function values that have not been evaluated are considered as stochastic functions. Thus, a G...

Model-Based Powertrain Control: Many Uses, No abuse — Many meanings exist behind this expression. We have conducted a mini-survey to confirm and describe this diversity. “Models” mainly stands for powertrain-models or Engine Management System (EMS) models. Uses are also very diverse, from upstream design activity to final software validation, through Model In the Loop and Software In the Loop t...

cellular proliferations that originate from the submucosa, and are histologically composed of fibrous tissues, blood vessels, and an inflammatory cell infiltrate containing a high percentage of eosinophils within an edematous and collagenous stroma (1). IFPs are most frequently found in the gastric antrum and the small bowel (1). Although the pathogenesis of gastric IFPs remains uncertain, some...