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Helicobacter pylori infection causes inflammation and increases the expression of IL-8 in human gastric epithelial cells. H. pylori activates NF-kappaB and AP-1, essential transcriptional factors in H. pylori-induced IL-8 gene transcription. Although colonization creates a local oxidative stress, the molecular basis for the transition from infection to the expression of redox-sensitive cytokine...
Pancreatic cancer is especially a deadly form of cancer with a survival rate less than 2%. Pancreatic cancers respond poorly to existing chemotherapeutic agents and radiation, and progress for the treatment of pancreatic cancer remains elusive. To address this unmet medical need, a better understanding of critical pathways and molecular mechanisms involved in pancreatic tumor development, progr...
In continuation of our interest in the synthesis of biologically active, natural and synthetic compounds, we have come across some surprises even with simple reactions like alkylation, condensation and rearrangement, which have resulted in the formation of some unusual novel products. Structures of these were assigned on the basis of their detailed spectral analysis and also confirmed in a few ...
There is a growing need to combine traditional relational data with new object feature into one integrated systems called as object-relational database management system (ORBMS) (Dorsey and Hudicka, 1999; Taniar, Rahayu and Srivastava, 2003). ORBMS is built based on SQL3 model, which consist object data types, row types, collection and abstract data types along with basic relational models (Car...
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