Mesial temporal sclerosis (MTS) is the most common cause of drug-resistant temporal lobe epilepsy in adults. Despite nearly 2 centuries since the first reports of MTS, relatively little is known about its etiology and pathogenesis. Increasing attention has been directed toward the potential role of vascular abnormalities in MTS. We evaluated the hippocampal microvasculature in 9 MTS cases and 3...

ECP: extracorporeal photopheresis HNPCC: hereditary nonpolyposis colorectal carcinoma ICL: interstrand crosslink MF: mycosis fungoides MMR: mismatch repair MSI: microsatellite instability MSI-H: high levels of microsatellite instability MTS: Muir-Torre syndrome PUVA: psoralen plus ultraviolet A INTRODUCTION Muir-Torre syndrome (MTS) is a rare, hereditary, autosomal dominant cancer syndrome that...

Multivariate Time-Series (MTS) are ubiquitous, and are generated in areas as disparate as sensor recordings in aerospace systems, music and video streams, medical monitoring, and financial systems. Domain experts are often interested in searching for interesting multivariate patterns from these MTS databases which can contain up to several gigabytes of data. Surprisingly, research on MTS search...

Among the heavy metal-binding ligands in plant cells the phytochelatins (PCs) and metallothioneins (MTs) are the best characterized. PCs and MTs are different classes of cysteine-rich, heavy metal-binding protein molecules. PCs are enzymatically synthesized peptides, whereas MTs are gene-encoded polypeptides. Recently, genes encoding the enzyme PC synthase have been identified in plants and oth...

Muir-Torre syndrome (MTS) is a rare inherited cancer syndrome with variable penetrance. MTS follows an autosomal-dominant pattern of inheritance, and is a subtype of Lynch syndrome [formally known as hereditary non-polyposis colorectal cancer (HNPCC)]. MTS is caused by mutations in one of several mismatch repair genes. Patients typically present with sebaceous neoplasms (sebaceous adenoma, seba...

This report discusses the cross-section shapes and growth curves created by different proliferation algorithms in an in silico model of in vitro multicellular tumor spheroid growth (MTS). The in vitro MTS system is a model of in vivo tumor growth. The in silico model described herein represents aspects of MTS growth, including its layered structure and growth patterns. An exploration of four al...

Assembly of the mitotic spindle is a classic example of macromolecular self-organization. During spindle assembly, microtubules (MTs) accumulate around chromatin. In centrosomal spindles, centrosomes at the spindle poles are the dominating source of MT production. However, many systems assemble anastral spindles, i.e., spindles without centrosomes at the poles. How anastral spindles produce and...

Many end-to-end feedback flow control protocols experience the rate oscillations caused by latency phase shift (LPS). This problem comes from time-varying bandwidth and non-zero feedback latency. A temporal flow control (TFC) protocol called MTS (Multiple-Time-Scale) was proposed to significantly reduce the oscillations in our earlier publication [2]. In this paper, the class of temporal flow c...

Polyglutamylases are enzymes that form polyglutamate side chains of variable lengths on proteins. Polyglutamylation of tubulin is believed to regulate interactions of microtubules (MTs) with MT-associated proteins and molecular motors. Subpopulations of MTs are differentially polyglutamylated, yet only one modifying enzyme has been discovered in mammals. In an attempt to better understand the h...

Cortical microtubules (MTs) participate in the spatial control of cell expansion and division that is required for plant growth and morphogenesis. Well-ordered transverse cortical MTs promote cell elongation and restrict radial cell expansion. The molecular mechanism controlling their ordering is poorly understood. We report the first known signaling pathway that promotes the organization of co...