Two epitopes have been identified recently to be responsible for the high-affinity binding of alkane-bisammonium and caracurine V type allosteric ligands to N-methylscopolamine (NMS)-occupied M2 muscarinic acetylcholine receptors, relative to M5 receptors: the amino acid M2-Thr423 at the top of transmembrane region (TM) 7 and an epitope comprising the second extracellular loop (o2) of the M2 re...

The nuclear receptor co-repressor (N-CoR) is a key component of the generic co-repressor complex that plays an important role in the control of cellular growth and differentiation. As shown by us recently, the growth suppressive function of N-CoR largely relies on its capacity to repress Flt3, a key regulator of cellular gorwth during normal and malignant hematopoesis. We further demonstrated h...

We study the geometry of M5-branes wrapping a 2-cycle which is Special Lagrangian with respect to a specific complex structure in a CalabiYau two-fold. Using methods recently applied to the three-fold case, we are again able find a characterization of the geometry, in terms of a nonintegrable almost complex structure and a (2,0) form. This time, however, due to the hyper-Kähler nature of the un...

Three studies (Ns = 183, 75, 123) examined the utility of the M5 Questionnaire (McCord, 2002), based on the five-factor model of personality (FFM), in assessing psychopathic personality traits in three separate undergraduate college student samples from the same public university in the Southeastern United States. Participants completed the M5 Questionnaire, a 336-item FFM instrument derived fr...

We discuss long-distance, low-velocity interaction potentials for processes involving longitudinal M5-brane (corresponding in type IIA theory language to the 1/4 supersymmetric bound state of 4-brane and 0-brane). We consider the following scattering configurations: (a) D = 11 graviton off longitudinal M5-brane, or, equivalently, 0-branes off marginal 4‖0 bound state; (b) M2-brane off longitudi...

Molecular mimicry between Streptococcus pyogenes Ags and human proteins has been considered as a mechanism leading to autoimmune reactions in rheumatic fever and rheumatic heart disease (RHD). Cardiac myosin has been shown as a putative autoantigen recognized by autoantibodies of rheumatic fever patients. We assessed the human heart-intralesional T cell response against human light meromyosin (...

BACKGROUND Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and decrease bone resorption. Thus, in...