Chemists, like artists, are able to construct new threedimensional objects, molecules and materials that exist only in the mind of a person. I became interested in creating novel molecular shapes with properties different from those found in nature shortly after arriving at Caltech in 1973. One cannot design without the brushes and paint of the craft. Indeed, modern organic chemists, standing o...

Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drug research and development endeavor. The ability to design elegant and economical synthetic routes is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach, introduced and advanced by Prof. E. J. Corey of Harvard University has served as a powerful driv...

Saucedo, Corey K. Goldman, John Blebea, Jennifer Macko, Paul D. Kessler, Henrik S. Sanjay Rajagopalan, Emile R. Mohler III, Robert J. Lederman, Farrell O. Mendelsohn, Jorge F. Claudication of Vascular Endothelial Growth Factor 121 in Patients With Disabling Intermittent Disease : A Phase II Randomized, Double-Blind, Controlled Study of Adenoviral Delivery Regional Angiogenesis With Vascular End...

Addition of lithiated alkyl dithianes to benzoyl chloride or methyl benzoate does not produce the expected product of double addition, alpha,alpha-bis(alkyldithianyl) benzyl alcohol, for alkyls larger than methyl. Instead, the first step intermediate, i.e. 2-benzoylated dithiane, undergoes an electron-transfer reduction by the second molecule of the dithianyl anion. This reduction is followed b...

Frederick W. Alt Don L. Anderson Michael Ashburner Stephen J. Benkovic David E. Bloom Floyd E. Bloom Piet Borst Henry R. Bourne Michael S. Brown James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Paul J. Crutzen James E. Dahlberg Robert Desimone Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Klaus Friedrich Theodore H. Geballe ...

In this paper we consider the process of one-dimensional redistribution of two immiscible and incompressible uids in a heterogeneous porous medium. We treat in detail the special case in which the initial saturation as well as the properties of the porous medium have a single coinciding discontinuity. Then the time-dependent saturation proole is of self-similar form, i.e. depends only on x= p t...

William T. Golden Treasurer Richard S. Nicholson Executive Officer John Abelson Frederick Alt Don L. Anderson Stephen J. Benkovic Gunter K-J Blobel Floyd E. Bloom Henry R. Boume James J. Bull Kathryn Calame Charles R. Cantor Ralph J. Cicerone John M. Coffin Robert Dorfman Bruce F. Eldridge Paul T. Englund Federic S. Fay Harry A. Fozzard Theodore H. Gaballe Roger 1. M. Glass Stephen J. Goff Core...

Which Biomarkers Reveal Neonatal Sepsis? Supplementary Material Kun Wang, Vineet Bhandari, Sofya Chepustanova, Greg Huber, Stephen O’Hara, Corey S. O’Hern, Mark D. Shattuck, Michael Kirby 1 Department of Mathematics, Colorado State University, Fort Collins, CO, USA 2 Department of Mechanical Engineering & Materials Science, Yale University, New Haven, CT, USA 3 Division of Perinatal Medicine, D...

C. Thomas Caskey Dennis W. Choi John M. Coffin F. Fleming Crim Paul J. Crutzen James E. Dahlberg Robert Desimone Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Klaus Friedrich Theodore H. Geballe Roger 1. M. Glass Stephen P. Goff Peter N. Goodfellow Corey S. Goodman Ira Herskowitz Eric F. Johnson Stephen M. Kosslyn Michael LaBarbera Nicole Le Douarin C...

Cormac Toher,1 Corey Oses,1 Jose J. Plata,1 David Hicks,1 Frisco Rose,1 Ohad Levy,1,2 Maarten de Jong,3,4 Mark Asta,3 Marco Fornari,5 Marco Buongiorno Nardelli,6 and Stefano Curtarolo7,* 1Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina 27708, USA 2Department of Physics, NRCN, Beer-Sheva, 84190, Israel 3Department of Materials Science and Engin...