Acute gastroenteritis is associated with high mortality in childhood. A complication of the illness is dehydration, which should be well managed. This study aimed to analyze the effect of metoclopramide on the number of vomiting episodes in moderately dehydrated children with acute gastroenteritis. In this single-blinded clinical trial, 240 children of 1 to 7 years old with acute viral gastroen...

OBJECTIVE To evaluate the effect of gabapentin on the incidence and severity of postoperative nausea and vomiting (PONV) after open cholecystectomy. SUBJECTS AND METHODS A total of 90 patients scheduled for elective open cholecystectomy were randomly assigned to either a gabapentin group (600 mg, 2 h before surgery) or a placebo group. For the analysis, 1 patient was excluded from the gabapen...

OBJECTIVE The objective of this study is to compare the efficacy and tolerability of intravenous valproic acid (iVPA) with intramuscular metoclopramide + subcutaneous (SQ) sumatriptan for prolonged acute migraine. BACKGROUND Intravenous valproic acid has been explored as a possible treatment of acute migraine. Sumatriptan and newer generation triptans are also effective for migraine. However,...

Editor—We have recently performed a systematic review assessing the efficacy of metoclopramide 10 mg for the prophylaxis against intraoperative and postoperative nausea and vomiting (IONV and PONV) in women undergoing Caesarean delivery under neuraxial anaesthesia. Shortly after the publication of our review, doubts have been raised regarding the validity of data included in the articles by Fuj...

BACKGROUND Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odd...

INTRODUCTION The use of prokinetic agents on post-pyloric placement of spiral nasojejunal tubes is controversial. The aim of the present study was to examine if metoclopramide or domperidone can increase the success rate of post-pyloric placement of spiral nasojejunal tubes. METHODS A multicenter, open-label, randomized, controlled trial was conducted in seven hospitals in China between April...

Background Dopamine D2-like receptors are attenuated in aldosterone producing adenoma, lead to overproduction of aldosterone in affected patients, and thus reported to serve as a potential treatment target for primary aldosteronism. The D2 dopamine receptor agonist bromocriptine has been used clinically for reducing tumor mass of pituitary adenomas of lactotroph origin. The aim of the present s...

introduction: headache is the most common neurologic symptom among referees to the emergency department (ed), while the best treatment has not yet been found. therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. methods: this study was a double-blind randomized clinical trial performed in imam khomeini...

Although the incidence of extrapyramidal reactions associated with metoclopramide has been reported to be approximately 0.2%, such reactions are rare in the anesthetic field. Several anesthetic adjuvants, including ondansetron and pregabalin, have also been associated with extrapyramidal side effect. Here, the authors report the case of a 47-year-old patient, previously administered pregabalin ...

A method is described for the simultaneous measurement of flow rate, mean transit time, and volume of the intestine during the transport of fluid through a segment of the small intestine of the dog. Using this method, the effect of metoclopramide on motility of the small bowel was assessed. The drug resulted in a decrease in transit time and volume in the test segment of bowel while the flow ra...