John Kriesel, MD; Bryce Moulton; Cammie Barrus NP; Michael Vaughn, BS; Robert Crisp, PhD; Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT; Infectious Diseases, University of Utah, Salt Lake City, UT; Salt Lake Valley Health Department, Salt Lake City, UT; Biofire Diagnostics, LLC, Salt Lake City, UT; Research and Development/Biochemistry, Biofire Diagnostics, LLC,...

Gstraunthaler, Gerhard, Thomas Holcomb, Elisabeth Feifel, Wenlin Liu, Nikolaus Spitaler, and Norman P. Curthoys. Differential expression and acid-base regulation of glutaminase mRNAs in gluconeogenic LLC-PK1FBPase1 cells. Am. J. Physiol. Renal Physiol. 278: F227– F237, 2000.—LLC-PK1-FBPase cells, which are a gluconeogenic substrain of porcine renal LLC-PK1 cells, exhibit enhanced oxidative meta...

Cancer cachexia describes the progressive skeletal muscle wasting and weakness in many cancer patients and accounts for >20% of cancer-related deaths. We tested the hypothesis that antibody-directed myostatin inhibition would attenuate the atrophy and loss of function in muscles of tumor-bearing mice. Twelve-week-old C57BL/6 mice received a subcutaneous injection of saline (control) or Lewis lu...

The cowpox virus (CPV) CrmA and the equivalent rabbitpox virus (RPV) SPI-2 proteins have anti-inflammatory and antiapoptosis activity by virtue of their ability to inhibit caspases, including the interleukin-1beta-converting enzyme (ICE; caspase-1). Infection of LLC-PK1 pig kidney cells with a CPV CrmA mutant, but not with wild-type (wt) CPV, results in the induction of many of the morphologica...

BACKGROUND Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthrocyclines. Pro and Raz are bisdioxopiperazine compounds. In this work, we evaluated the anti-tumor and anti-metastatic effects of Pro and Raz in vivo against two lung tumor model...

GoldSim is a powerful and flexible Windows-based computer program for carrying out probabilistic simulations of complex systems to support management and decision-making in engineering, science and business. The program is highly graphical, highly extensible, able to directly represent uncertainty, and allows you to create compelling presentations of your model. Although GoldSim can be used to ...

The involvement of platelets in tumor progression is well recognized. The depletion of circulating platelets or pharmacologic inhibitors of platelet activation decreases the metastatic potential of circulating tumor cells in metastasis mouse models. The platelet ADP receptor P2Y12 amplifies the initial hemostatic responses activated by a variety of platelet agonists and stabilizes platelet aggr...

Autophagy is a self-defense mechanism that provides nutrition and energy for cell survival by recycling the cytoplasm and organelles. Hence, chemotherapy is rendered less effective against cancer cells. Evodiamine is a previously described biological agent that possesses a cytotoxic activity in multiple cancer cells. However, little is known about evodiamine-induced autophagy in Lewis lung carc...