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Acute respiratory distress syndrome represents a complex syndrome with considerable morbidity and mortality, for which there exist no targeted treatment strategies. However, recent advances in clinical care have improved outcomes, and we will review a number of these approaches here, as well as explore the mechanisms underlying the benefit of intervention that might point us in the direction to...

BACKGROUND Nutrition screening on admission to hospital is mandated in many countries, but to date, there is no consensus on which tool is optimal in the oncology setting. Wasting conditions such as cancer cachexia (CC) and sarcopenia are common in cancer patients and negatively impact on outcomes; however, they are often masked by excessive adiposity. This study aimed to inform the application...

PURPOSE To analyze the utilization and fractionation of extreme hypofractionation via stereotactic body radiotherapy (SBRT) in the treatment of prostate cancer. MATERIALS AND METHODS Data was analyzed on men diagnosed with localized prostate cancer between 2004-2012 and treated with definitive-intent radiation therapy, as captured in the National Cancer Database. This database is a hospital-b...

BACKGROUND Arterial hemoglobin oxygen saturation (SaO₂) decreases at an altitude of >1,500 m. There are no reports on normal SaO₂ at altitudes between 0 and 1,500 m. The clinical significance of decreased SaO₂ at such altitudes is unclear. OBJECTIVE To test the hypothesis that in healthy volunteers normal SaO₂ at moderate altitude (MA; 725 m) is lower than that at almost sea level (SL; 43 m)....

Abstract Aim: To evaluate guideline compliance of antibiotics prescription in Emergency Department (ED). improve documentation antibiotic prescription. highlight the need for good stewardship. optimise use antibiotics. Method A cross-sectional, retrospective patient record review was conducted regarding over 1 month Sheffield Children’s Hospital ED. All prescriptions that period were collected....