EGFR mutations correlate with improved clinical outcome whereas KRAS mutations are associated with lack of response to tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). Endobronchial ultrasound (EBUS)-transbronchial needle aspiration (TBNA) is being increasingly used in the management of NSCLC. Co-amplification at lower denaturation temperature (COLD)-polymerase ch...

BACKGROUND/PURPOSE Today's medical students are learning in a social media era in which patient confidentiality is at risk yet schools' social media policies have not been elucidated. The purpose of this study is to describe the presence of medical schools on top social media sites and to identify whether student policies for these schools explicitly address social media use. METHOD Websites ...

Purpose: Both PARP inhibitors (PARPi) and sacituzumab govitecan (IMMU-132) are currently under clinical evaluation in triple-negative breast cancer (TNBC). We sought to investigate the combined DNA-damaging effects of the topoisomerase I (Topo I)-inhibitory activity of IMMU-132 with PARPi disruption of DNA repair in TNBC.Experimental Design:In vitro, human TNBC cell lines were incubated with IM...

We prove that the total number Sn,132(q) of copies of the pattern q in all 132avoiding permutations of length n is the same for q = 231, q = 312, or q = 213. We provide a combinatorial proof for this unexpected threefold symmetry. We then significantly generalize this result by proving a large family of non-trivial equalities of the type Sn,132(q) = Sn,132(q ). Dedicated to the memory of Herb Wilf

We generalize the definition of a pattern from permutations to alternating sign matrices. The number of alternating sign matrices avoiding 132 is proved to be counted by the large Schröder numbers, 1, 2, 6, 22, 90, 394 . . .. We give a bijection between 132-avoiding alternating sign matrices and Schröder-paths, which gives a refined enumeration. We also show that the 132, 123avoiding alternatin...

The use of NADH- and NADPH-dependent ketoreductases to access enantioenriched pharmaceutical building blocks is reported. Seven structurally diverse synthons are obtained, including those for atomoxetine (KRED 132), talampanel (RS1-ADH and CPADH), Dolastatin (KRED 132), and fluoxetine (KRED 108/132). Ethanol may be used as stoichiometric reductant, regenerating both nicotinamide cofactors, part...