Cyclic adenosine monophosphate response element binding (CREB)-binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble large regulatory complexes at sites of active transcription. Nullizygosity of CBP or p300 results in pervasive defects in hematopoiesis. To systematically assess the structural domains of p300 required for normal hematopoiesis, we used rec...

AIM In the present study, the P300 component of the emotion-loaded visual event-related potential in response to photographs of babies crying or smiling was measured to evaluate cognitive function in elderly subjects, including those with dementia. METHODS The subjects were 48 elderly people who consulted a memory disorder clinic. The visual event-related potential was measured using oddball ...

NF-κB plays a vital role in cellular immune and inflammatory response, survival, and proliferation by regulating the transcription of various genes involved in these processes. To activate transcription, RelA (a prominent NF-κB family member) interacts with transcriptional co-activators like CREB-binding protein (CBP) and its paralog p300 in addition to its cognate κB sites on the promoter/enha...

Evaluation of cognitive functions in Parkinson’s patients without dementia with auditory event related potential (P300) Objective: Idiopathic Parkinson’s disease is a clinical situation characterized by akinesia, rigidity, and tremor, and results from the degeneration of the dopaminergic nervous system. As the disease progresses over time, depression, cognitive dysfunction and alterations in co...

The purpose of this study was to determine whether certain previously reported relationships between event-related potentials and measures of signal detection performance occur in vigilance as well as psychophysical settings. In the course of the study, evidence was found which challenges previously proposed psychological correlates of "P300". EEG was recorded while 15 subjects carried out a 40...

Using a stepwise discriminant analysis, we demonstrate that the amplitude of P300 is a graded function of the complexity of information processing required of a S following a stimulus. This relationship between cognitive complexity and P300 is apparent only when the S is not pressed to generate fast and accurate discriminant responses to the stimuli. Under a reaction-time regime, a large P300 i...

The P300 component of Event Related Brain Potentials (ERP) is commonly used in Brain Computer Interfaces (BCI) to translate the intentions of an individual into commands for external devices. The P300 response, however, resides in a signal environment of high background noise. Consequently, the main problem in developing a P300-based BCI lies in identifying the P300 response in the presence of ...

Prior work has consistently revealed a relationship between antisocial behavior and reduced P300 amplitude. Fewer studies have directly evaluated behavioral indices of aggression and P300, and those that have generally do not account for potential mediating variables such as age, intelligence, and behavioral task performance. The current study assessed the relationship between the total number ...

An effective new platform for phosphosite mapping and subsequent functional screening was developed to analyze the targeted protein-protein interactions of p300 and CBP with β-catenin. Two novel functional phosphosites, Ser12 of p300 and Ser92 of CBP, were revealed to modulate p300/β-catenin and CBP/β-catenin interactions, respectively.