p53 tumor suppressor gene therapy has been proposed for cancers characterized by inactivation of p53 function, and successful therapy will require efficient strategies for gene delivery. To maximize transgene expression in tumors, a clinical strategy has been proposed to treat neoplasms in the liver via hepatic artery administration of a recombinant adenovirus encoding wild-type p53 (rAd-p53). ...

BACKGROUND Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD). AIMS To examine whether neural activity during reward processing was altered in children and adolescents with RAD. METHOD Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergo...

BACKGROUND Lower cranial neuropathies are a late effect of radiotherapy (RT), typically reported in nasopharyngeal cancer survivors. Limited data examine these neuropathies after oropharyngeal cancer, particularly as it relates to late radiation-associated dysphagia (late-RAD). METHODS Two cases were examined over 4 to 6 years. Late-RAD was assessed per MBS impairment profile (MBSImP™©), Pene...

Massively parallel sequencing has revolutionized many areas of biology, but sequencing large amounts of DNA in many individuals is cost-prohibitive and unnecessary for many studies. Genomic complexity reduction techniques such as sequence capture and restriction enzyme-based methods enable the analysis of many more individuals per unit cost. Despite their utility, current complexity reduction m...

We revealed the cytotoxic effect of the flavonoid, fisetin (FIS), on human COLO205 colon cancer cells in the presence and absence of the HSP90 inhibitors, geldanamycin (GA) and radicicol (RAD). Compared to FIS treatment alone of COLO205 cells, GA and RAD significantly enhanced FIS-induced cytotoxicity, increased expression of cleaved caspase-3 and the PAPR protein, and produced a greater densit...

This paper presents an FPGA-based Solid State Drive (SSD) architecture for data-intensive applications called Reconfigurable Active Drive (RAD). In the RAD architecture, an FPGA utilizes parallel data transfer of flash memory to improve the data throughput for streaming applications. The storage architecture is designed to match the I/O bandwidth of the FPGA and is capable of fully parallelizin...

Parsec scale Faraday rotation measure maps are presented for the radio galaxies M87, 3C 111, and 3C 120. These VLBA observations were made at 8, 12, and 15 GHz. M87 has an extreme RM distribution which varies from −4000 rad m −2 to more than 9000 rad m −2 across a projected distance of 0.3 parsecs in its jet. M87 has no polarized flux closer than 17 mas from the core. 3C 111 and 3C 120 both sho...

BACKGROUND There is a long history of coronary heart disease (CHD) diagnosis and treatment in Chinese medicine (CM), but a formalized description of CM knowledge is still unavailable. This study aims to analyze a set of CM clinical data, which is important and urgent. METHODS Relative associated density (RAD) was used to analyze the one-way links between the symptoms or syndromes or both. RAD...

MOTIVATION The innovation of restriction-site associated DNA sequencing (RAD-seq) method takes full advantage of next-generation sequencing technology. By clustering paired-end short reads into groups with their own unique tags, RAD-seq assembly problem is divided into subproblems. Fast and accurately clustering and assembling millions of RAD-seq reads with sequencing errors, different levels o...

Blood volume expands significantly during pregnancy, but afferent signals from cardiac receptors are reduced. In addition, during exogenous volume expansion, right atrial pressure (RAP) increases more for equivalent volumes in pregnant animals, implying reduced atrial compliance. To examine possible gestational alterations in atrial dimension during volume expansion, we compared the effects of ...