BACKGROUND Isolated cleft mitral valve (ICMV) may occur alone or in association with other congenital heart lesions. The aim of this study was to describe the profile of cardiac lesions associated with ICMV and their potential impact on therapeutic management. METHODS We conducted a descriptive study with data retrieved from the Congenital Heart Disease (CHD) single-center registry of our ins...

Insertional mutagenesis experiments performed on Drosophila melanogaster model often relies on induced mobilization of artificial transposons derived from P mobile element. In an attempt to detect transposition preferences, we accomplished a pilot study concerning the insertional patterns of P{lacW} and P{EP} constructs in the third chromosome of D. melanogaster. Our inventory inquiry considere...

Semaphorins play important regulatory roles in diverse processes such as axon guidance, angiogenesis, and immune responses. We find that semaphorin-3C (sema3C) induces the collapse of the cytoskeleton of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1–dependent manner, while most other semaphorins, including antiangiogenic semaphorins such as sema3A do not. Sema3...

Three new ligands of the general formula [RNHCH(py)(2)] (py = pyridine; R = tosyl, Ts-dpm; R = dansyl, Ds-dpm; R = 7-nitro-1,2,3-benzoxadiazole, NBD-dpm) have been synthesized and characterized. Reactions of these ligands with cis-[Pt(DMSO)(2)Cl(2)] (DMSO = dimethyl sulfoxide) in methanol affords [Pt(Ts-dpm)Cl(2)] (1), [Pt(Ds-dpm)Cl(2)] (2), and [Pt(NBD-dpm)Cl(2)] (3). The crystal structures of...

© 2017 Dental Press Journal of Orthodontics Dental Press J Orthod. 2017 May-June;22(3):9-10 9 Today’s orthodontics has substantially reduced the need for extractions. One of the reasons for this change in approach is based on the findings of studies published in the early 1980s by researchers at the University of Washington, who reported similar rates of teeth alignment relapse in cases treated...

OBJECTIVE To examine use of thrombolytic drugs for myocardial infarction and use of contraindications to treatment in the United Kingdom. DESIGN Observational study, based on a continuing audit. SETTING 39 hospitals in the United Kingdom. PATIENTS 30,029 patients admitted between November 1992 and June 1995 with suspected myocardial infarction. RESULTS Of 13,628 patients with a final di...

Abstract Background Though cervical cancer is one of the leading causes cancer-related death globally, its incidence nearly entirely preventable. Young people have been an international priority for screening as this population has historically under-screened. However, in both high-income and low-income countries, young not screened appropriately according to country-specific guidelines. The ai...