g-Radiation is a potent inducer of apoptosis. There are multiple pathways regulating DNA damage-induced apoptosis, and we set out to identify novel mechanisms regulating g-radiation–induced apoptosis in hematopoietic cells. In this report, we present data implicating the cyclin B1 protein as a regulator of apoptotic fate following DNA damage. Cyclin B1 is the regulatory subunit of the cdc2 seri...

EphB2 is a receptor tyrosine kinase of the Eph family and ephrin-B1 is one of its transmembrane ligands. In the embryo, EphB2 and ephrin-B1 participate in neuronal axon guidance, neural crest cell migration, the formation of blood vessels, and the development of facial structures and the inner ear. Interestingly, EphB2 and ephrin-B1 can both signal through their cytoplasmic domains and become t...

Introduction: At high magnetic field strengths (≥3T) the RF wavelength becomes smaller than the sample size, making transmit magnetic field (B1) inhomogeneity more prominent. RF-shimming [1] and Transmit SENSE [2] have been proposed as methods to minimize this inhomogeneity. To take advantage of these methods it is important to accurately map the B1 field. Saturation prepared with 2 RApid Gradi...

Temperature-sensitive (ts) mutants of vaccinia virus defective in the B1 kinase demonstrate a conditionally lethal defect in DNA synthesis. B1 is the prototypic member of a new family of protein kinases (vaccinia virus-related kinases, or VRK) that possess distinctive B1-like sequence features within their catalytic motifs (R. J. Nichols and P. Traktman, J. Biol. Chem., in press). Given the str...

Five experimental groups were used to evaluate the efficiency of sodium bentonite (BNT) and ascorbic acid (AA) in reducing the toxicity of aflatoxin B1 in ElSalam chicks (Egyptian local chicks) diets. A total number of 450 unsexed one-day old chicks were wing banded, weighted and randomly assigned to 5 groups of five replicates (18 chicks/replicate). The experimental groups were as follow: 1) b...

A 3-year comprehensive analysis of aflatoxin contamination in peanut butter was conducted in Zambia, sub-Saharan Africa. The study analyzed 954 containers of 24 local and imported peanut butter brands collected from shops in Chipata, Mambwe, Petauke, Katete, and Nyimba districts and also in Lusaka from 2012 to 2014. For analysis, a sample included six containers of a single brand, from the same...

Given three mutually tangent circles with bends (or the reciprocal of the radius) a, b and c respectively, an important quantity associated with the triple is the value 〈a, b, c〉 := ab + ac + bc. In this note we show in the case when a central circle with bend b0 is “surrounded” by four circles, i.e., a flower with four petals, with bends b1, b2, b3, b4 that either p 〈b0, b1, b2〉 + p 〈b0, b3, b...

Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors. To address this discrepancy, we conducted a meta-analysis with 17 published studies searched from PubMed and Medline. Cyclin B...

Hybridomas that secreted antibodies for aflatoxin B1 were selected using two immunization protocols referred to as A and B. Protocol A is a standard immunization method and resulted in the selection of only two clones that produced monoclonal antibodies against aflatoxin B1. In protocol B a unique immunization schedule which resulted in the generation of 10 hybridomas is described. Of the 10, o...

Proof: We proved in class (Proposition 2.4.1) that there is at least one triangle-or-anti-triangle, call its vertices {a1, a2, a3}. There are at least three additional distinct vertices, b1, b2, and b3. If all of b1, b2, and b3 are adjacent to each other, then {b1, b2, b3} is a triangle. If none of b1, b2, and b3 is adjacent to any other, then {b1, b2, b3} is an anti-triangle. Assume without lo...