......................................................................................................V SAMMANFATTNING ................................................................................... VII TABLE OF CONTENTS ................................................................................. IX LIST OF PAPERS............................................................................

............................................................................................................. V LIST OF PAPERS ................................................................................................. VII ABBREVIATIONS ..............................................................................................XIII

.................................................................................................................................................. I LIST OF PUBLICATIONS....................................................................................................................... III PREFACE....................................................................................................

abstract  introduction: during extrinsic coagulation pathway, a complex is developed between factor vii, calcium and tissue factor (a cell membrane lipoprotein that is exposed after cell injury). factor vii needs calcium and vitamin k for its biologic activation. coronary artery disease (cad) can be induced by increased level and activity of the coagulation factors vii, viii and ix. in postmeno...

The Ca(2+) sensor synaptotagmin (Syt) VII regulates the exocytosis of conventional lysosomes in several cell types. In CTLs, the Ca(2+)-regulated exocytosis of lytic granules/secretory lysosomes is responsible for the perforin/granzyme-mediated lysis of target cells. To investigate the role of Syt VII in CTL effector function, the expression and function of Syt VII were examined in wild-type an...

Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (ProthrombinProconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The aim ...

.....................................................................................................I POPULÄRVETENSKAPLIG SAMMANFATTNING .......................................III PREFACE....................................................................................................... V PUBLICATIONS INCLUDED IN THE THESIS............................................. VII RELATED PUBLICATIO...

................................................................................................................................. V List of Tables ............................................................................................................................. VII List of Figures ...........................................................................................................