نتایج جستجو برای: فاکتور القاکنندۀ هایپوکسی hif

تعداد نتایج: 23880  

2010
Daniela Trisciuoglio Chiara Gabellini Marianna Desideri Elio Ziparo Gabriella Zupi Donatella Del Bufalo

BACKGROUND Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is a critical mediator of the cellular response to hypoxia. Enhanced levels of HIF-1alpha, the oxygen-regulated subunit of HIF-1, is often associated with increased tumour angiogenesis, metastasis, therapeutic resistance and poor prognosis. It is in this context that we previously demonstrated that under hypoxia, bcl-2...

2003
Yang-Sook Chun Kyoung-Hwa Lee Eunjoo Choi Soo-Young Bae Eun-Jin Yeo L. Eric Huang Myung-Suk Kim Jong-Wan Park

Hypoxia-inducible factor-1 (HIF-1), which is present at higher levels in human tumors, plays important roles in tumor promotion. It is composed of HIF-1 and HIF-1 subunits and its activity depends on the amount of HIF-1 , which is tightly controlled by cellular oxygen tension. In addition to hypoxia, various nonhypoxic stimuli can stabilize HIF-1 in tumor cells, implying that both hypoxic and n...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2014
Xiang Xue Sadeesh K Ramakrishnan Yatrik M Shah

The hypoxic response is mediated by two transcription factors, hypoxia-inducible factor (HIF)-1α and HIF-2α. These highly homologous transcription factors are induced in hypoxic foci and regulate cell metabolism, angiogenesis, cell proliferation, and cell survival. HIF-1α and HIF-2α are activated early in cancer progression and are important in several aspects of tumor biology. HIF-1α and HIF-2...

Journal: :American journal of physiology. Endocrinology and metabolism 2011
Qing He Zhanguo Gao Jun Yin Jin Zhang Zhong Yun Jianping Ye

The transcription factor HIF-1α activity is increased in adipose tissue to contribute to chronic inflammation in obesity. However, its upstream and downstream events remain to be characterized in adipose tissue in obesity. We addressed this issue by investigating adipocyte HIF-1α activity in response to obesity-associated factors, such as adipogenesis, insulin, and hypoxia. In adipose tissue, b...

Journal: :International journal of clinical and experimental pathology 2014
Lin Zhang Shu-Biao Ye Ze-Lei Li Gang Ma Shi-Ping Chen Jia He Wan-Li Liu Dan Xie Yi-Xin Zeng Jiang Li

The expression of hypoxia-induced factor (HIF)-1α is up-regulated in tumor microenvironments under hypoxia condition. However, the prognostic significance of HIF-1α in esophageal squamous cell carcinoma (ESCC) is still elusive. We measured the HIF-1α expression by immunochemistry in tumor specimens from 136 resected ESCC; in the current study, the HIF-1α expression in tumor cells was significan...

2005
Bastian Eul Frank Rose Stefanie Krick Rajkumar Savai Parag Goyal Walter Klepetko Friedrich Grimminger Norbert Weissmann Werner Seeger Jörg Hänze

Proliferation of adventitial fibroblasts of small intrapulmonary arteries (FBPA) has been disclosed as an early event in the development of pulmonary hypertension and cor pulmonale in response to hypoxia. We investigated the role of hypoxia-inducible transcription factors (HIF) in human FBPA exposed to hypoxia. Primary cultures of FBPA displayed a strong mitogenic response to 24 h hypoxia, wher...

Journal: :Indonesian Journal of Electrical Engineering and Computer Science 2021

This paper proposes an analysis of high-impedance fault detection algorithms for medium voltage distribution lines based on the discrete wavelet transform (DWT) technique and a more advanced named independent component (ICA) independently. Three-phase line model two diodes high impedance model, which represents unsymmetrical current electric arc, simulated using MATLAB/Simulink. High (HIF) algo...

2014
Jlenia Guarnerio Nadia Coltella Ugo Ala Giovanni Tonon Pier Paolo Pandolfi Rosa Bernardi

Maintenance and differentiation of hematopoietic stem cells (HSCs) is regulated through cell-autonomous and non-cell-autonomous mechanisms within specialized bone marrow microenvironments. Recent evidence demonstrates that signaling by HIF-1α contributes to cell-autonomous regulation of HSC maintenance. By investigating the role of HIF factors in bone marrow mesenchymal progenitors, we found th...

2013
Sarah J. Welsh Aaron G. Dale Caterina M. Lombardo Helen Valentine Maria de la Fuente Andreas Schatzlein Stephen Neidle

The hypoxia-inducible transcription factor (HIF) co-ordinates the response of tumours to low oxygen by stimulating genes involved in metabolism and angiogenesis. HIF pathway activation is associated with decreased progression-free survival and increased mortality; compounds that target this pathway are potential agents for the treatment of a range of solid tumour malignancies. Renal cancers are...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Xiaowei Zheng Alex-Xianghua Zhou Pegah Rouhi Hidetaka Uramoto Jan Borén Yihai Cao Teresa Pereira Levent M Akyürek Lorenz Poellinger

The cellular response to hypoxia is regulated by hypoxia-inducible factor-1α and -2α (HIF-1α and -2α). We have discovered that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1α and promotes tumor growth and angiogenesis. Hypoxia induces a calpain-dependent cleavage of FLNA to generate a naturally occurring C-terminal fragment that accumulates in the ...

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